Asenapine and Rifampin Interaction
Drug interaction information between Asenapine and Rifampin.
Asenapine and Rifampin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Asenapine and Rifampin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Rifampin speeds up certain liver enzymes, but it does not change the levels of asenapine enough to cause a problem.
FDA Label Information
7.2 Drugs Having No Clinically Important Interactions with Asenapine No dosage adjustment of asenapine is necessary when administered concomitantly with paroxetine (see Table 12 in Drug Interactions (7.1) for paroxetine dosage adjustment), imipramine, cimetidine, valporate, lithium, or a CYP3A4 inducer (e.g., carbamazepine, phenytoin, rifampin).
Asenapine Also Interacts With
- Paroxetine minor
- Carbamazepine minor
- Lithium minor
- Imipramine minor
- Fluvoxamine minor
Rifampin Also Interacts With
- Darunavir major
- Bictegravir/Emtricitabine/Tenofovir major
- Glecaprevir/Pibrentasvir major
- Nirmatrelvir/Ritonavir major
- Pitavastatin major
Frequently Asked Questions
What SPL severity band is on file for Asenapine + Rifampin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rifampin has 137 labeled pairs on file vs Asenapine's 8. In the minor band specifically: Asenapine has 8 (also Paroxetine, Carbamazepine, Lithium, Imipramine); Rifampin has 103 (also Metoprolol, Losartan, Simvastatin, Glipizide).
What mechanism field is on file for Asenapine and Rifampin?
Rifampin speeds up certain liver enzymes, but it does not change the levels of asenapine enough to cause a problem.
Rifampin carries more major-labeled pairs than Asenapine
SPL source-record counts only. This page's band is minor · classes on file: Asenapine (Atypical Antipsychotic); Rifampin (Rifamycin Antibiotic).
Rifampin has 8 major-labeled pairs vs Asenapine's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 8 minor · 8 total
- Other minor peers for Asenapine
- Paroxetine
- Carbamazepine
- Lithium
- Imipramine
8 major · 26 moderate · 103 minor · 137 total
- Other minor peers for Rifampin
- Metoprolol
- Losartan
- Simvastatin
- Glipizide
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.