Asenapine and Carbamazepine Interaction
Drug interaction information between Asenapine and Carbamazepine.
Asenapine and Carbamazepine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Asenapine and Carbamazepine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Carbamazepine does not significantly change the levels of asenapine in your body.
FDA Label Information
7.2 Drugs Having No Clinically Important Interactions with Asenapine No dosage adjustment of asenapine is necessary when administered concomitantly with paroxetine (see Table 12 in Drug Interactions (7.1) for paroxetine dosage adjustment), imipramine, cimetidine, valporate, lithium, or a CYP3A4 inducer (e.g., carbamazepine, phenytoin, rifampin).
Asenapine Also Interacts With
- Paroxetine minor
- Lithium minor
- Rifampin minor
- Imipramine minor
- Fluvoxamine minor
Carbamazepine Also Interacts With
- Nirmatrelvir/Ritonavir major
- Ranolazine major
- Risperidone major
- Lithium moderate
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Asenapine + Carbamazepine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Carbamazepine has 129 labeled pairs on file vs Asenapine's 8. In the minor band specifically: Asenapine has 8 (also Paroxetine, Lithium, Rifampin, Imipramine); Carbamazepine has 110 (also Omeprazole, Ibuprofen, Citalopram, Amitriptyline).
What mechanism field is on file for Asenapine and Carbamazepine?
Carbamazepine does not significantly change the levels of asenapine in your body.
Carbamazepine carries more major-labeled pairs than Asenapine
SPL source-record counts only. This page's band is minor · classes on file: Asenapine (Atypical Antipsychotic); Carbamazepine (Anticonvulsant).
Carbamazepine has 3 major-labeled pairs vs Asenapine's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 8 minor · 8 total
- Other minor peers for Asenapine
- Paroxetine
- Lithium
- Rifampin
- Imipramine
3 major · 16 moderate · 110 minor · 129 total
- Other minor peers for Carbamazepine
- Omeprazole
- Ibuprofen
- Citalopram
- Amitriptyline
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.