Amiodarone and Lovastatin Interaction
Drug interaction information between Amiodarone and Lovastatin.
Amiodarone and Lovastatin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Amiodarone and Lovastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking amiodarone with lovastatin makes it harder for your body to process the cholesterol drug. This can lead to a buildup of lovastatin that may damage your muscles.
FDA Label Information
Amiodarone The risk of myopathy/rhabdomyolysis is increased when amiodarone is used concomitantly with a closely related member of the HMG-CoA reductase inhibitor class (see WARNINGS , Myopathy/Rhabdomyolysis ).
Amiodarone Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Nirmatrelvir/Ritonavir major
- Simvastatin major
- Lithium moderate
Lovastatin Also Interacts With
- Darunavir major
- Nirmatrelvir/Ritonavir major
- Spironolactone moderate
- Ketoconazole moderate
- Verapamil moderate
Frequently Asked Questions
What SPL severity band is on file for Amiodarone + Lovastatin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Amiodarone has 42 labeled pairs on file vs Lovastatin's 30. In the moderate band specifically: Amiodarone has 9 (also Lithium, Clarithromycin, Fluconazole, Ledipasvir/Sofosbuvir); Lovastatin has 17 (also Spironolactone, Ketoconazole, Verapamil, Cyclosporine).
What mechanism field is on file for Amiodarone and Lovastatin?
Taking amiodarone with lovastatin makes it harder for your body to process the cholesterol drug. This can lead to a buildup of lovastatin that may damage your muscles.
Amiodarone carries more major-labeled pairs than Lovastatin
SPL source-record counts only. This page's band is moderate · classes on file: Amiodarone (Class III Antiarrhythmic); Lovastatin (HMG-CoA Reductase Inhibitor (Statin)).
Amiodarone has 4 major-labeled pairs vs Lovastatin's 2. This page itself is in the moderate band, not the major band.
4 major · 9 moderate · 29 minor · 42 total
- Other moderate peers for Amiodarone
- Lithium
- Clarithromycin
- Fluconazole
- Ledipasvir/Sofosbuvir
2 major · 17 moderate · 11 minor · 30 total
- Other moderate peers for Lovastatin
- Spironolactone
- Ketoconazole
- Verapamil
- Cyclosporine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.