Amiodarone and Fluconazole Interaction
Drug interaction information between Amiodarone and Fluconazole.
Amiodarone and Fluconazole have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Amiodarone and Fluconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Using these drugs together can affect the electrical timing of your heartbeat, which may lead to a dangerous heart rhythm.
FDA Label Information
Amiodarone : Concomitant administration of fluconazole with amiodarone may increase QT prolongation. Caution must be exercised if the concomitant use of fluconazole and amiodarone is necessary, notably with high-dose fluconazole (800 mg).
Amiodarone Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Nirmatrelvir/Ritonavir major
- Simvastatin major
- Lithium moderate
Fluconazole Also Interacts With
- Pimozide major
- Clarithromycin major
- Eplerenone major
- Atorvastatin moderate
- Simvastatin moderate
Frequently Asked Questions
What SPL severity band is on file for Amiodarone + Fluconazole?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluconazole has 67 labeled pairs on file vs Amiodarone's 42. In the moderate band specifically: Amiodarone has 9 (also Lithium, Clarithromycin, Ledipasvir/Sofosbuvir, Lovastatin); Fluconazole has 7 (also Atorvastatin, Simvastatin, Carbamazepine, Fluvastatin).
What mechanism field is on file for Amiodarone and Fluconazole?
Using these drugs together can affect the electrical timing of your heartbeat, which may lead to a dangerous heart rhythm.
Amiodarone carries more major-labeled pairs than Fluconazole
SPL source-record counts only. This page's band is moderate · classes on file: Amiodarone (Class III Antiarrhythmic); Fluconazole (Azole Antifungal).
Amiodarone has 4 major-labeled pairs vs Fluconazole's 3. This page itself is in the moderate band, not the major band.
4 major · 9 moderate · 29 minor · 42 total
- Other moderate peers for Amiodarone
- Lithium
- Clarithromycin
- Ledipasvir/Sofosbuvir
- Lovastatin
3 major · 7 moderate · 57 minor · 67 total
- Other moderate peers for Fluconazole
- Atorvastatin
- Simvastatin
- Carbamazepine
- Fluvastatin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.