Amiodarone and Ledipasvir/Sofosbuvir Interaction
Drug interaction information between Amiodarone and Ledipasvir/Sofosbuvir.
Amiodarone and Ledipasvir/Sofosbuvir have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Amiodarone and Ledipasvir/Sofosbuvir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these drugs together can cause your heart rate to drop to a dangerously slow level. While the exact reason is unknown, the combination interferes with your heart's normal rhythm.
FDA Label Information
7 DRUG INTERACTIONS Coadministration with amiodarone may result in serious symptomatic bradycardia. Use of HARVONI with amiodarone is not recommended. Antiarrhythmics: amiodarone Effect on amiodarone, ledipasvir, and sofosbuvir concentrations unknown Coadministration of amiodarone with HARVONI may result in serious symptomatic bradycardia.
Amiodarone Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Nirmatrelvir/Ritonavir major
- Simvastatin major
- Lithium moderate
Ledipasvir/Sofosbuvir Also Interacts With
- Atorvastatin moderate
- Rifampin moderate
- Rosuvastatin moderate
- Rosuvastatin/Ezetimibe moderate
- Omeprazole minor
Frequently Asked Questions
What SPL severity band is on file for Amiodarone + Ledipasvir/Sofosbuvir?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Amiodarone has 42 labeled pairs on file vs Ledipasvir/Sofosbuvir's 22. In the moderate band specifically: Amiodarone has 9 (also Lithium, Clarithromycin, Fluconazole, Lovastatin); Ledipasvir/Sofosbuvir has 5 (also Atorvastatin, Rifampin, Rosuvastatin, Rosuvastatin/Ezetimibe).
What mechanism field is on file for Amiodarone and Ledipasvir/Sofosbuvir?
Taking these drugs together can cause your heart rate to drop to a dangerously slow level. While the exact reason is unknown, the combination interferes with your heart's normal rhythm.
Amiodarone carries more major-labeled pairs than Ledipasvir/Sofosbuvir
SPL source-record counts only. This page's band is moderate · classes on file: Amiodarone (Class III Antiarrhythmic); Ledipasvir/Sofosbuvir (NS5A/NS5B Inhibitor (HCV)).
Amiodarone has 4 major-labeled pairs vs Ledipasvir/Sofosbuvir's 0. This page itself is in the moderate band, not the major band.
4 major · 9 moderate · 29 minor · 42 total
- Other moderate peers for Amiodarone
- Lithium
- Clarithromycin
- Fluconazole
- Lovastatin
0 major · 5 moderate · 17 minor · 22 total
- Other moderate peers for Ledipasvir/Sofosbuvir
- Atorvastatin
- Rifampin
- Rosuvastatin
- Rosuvastatin/Ezetimibe
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.