Amiodarone and Clarithromycin Interaction
Drug interaction information between Amiodarone and Clarithromycin.
Amiodarone and Clarithromycin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Amiodarone and Clarithromycin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Clarithromycin can change how the body processes this heart medicine, which may increase the risk of dangerous heart rhythm problems.
FDA Label Information
Clinically Significant Drug Interactions with Clarithromycin Tablets Drugs That Are Affected By Clarithromycin Tablets Drug(s) with Pharmacokinetics Affected by Clarithromycin Tablets Recommendation Comments Antiarrhythmics: Disopyramide Quinidine Dofetilide Amiodarone Sotalol Procainamide Not Recommended Disopyramide, Quinidine: There have been postmarketing reports of torsades de pointes occurring with concurrent use of clarithromycin and quinidine or disopyramide.
Amiodarone Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Nirmatrelvir/Ritonavir major
- Simvastatin major
- Lithium moderate
Clarithromycin Also Interacts With
- Quetiapine major
- Pioglitazone major
- Fluconazole major
- Cyclosporine major
- Lurasidone major
Frequently Asked Questions
What SPL severity band is on file for Amiodarone + Clarithromycin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clarithromycin has 81 labeled pairs on file vs Amiodarone's 42. In the moderate band specifically: Amiodarone has 9 (also Lithium, Fluconazole, Ledipasvir/Sofosbuvir, Lovastatin); Clarithromycin has 35 (also Omeprazole, Methylprednisolone, Sildenafil, Valproate).
What mechanism field is on file for Amiodarone and Clarithromycin?
Clarithromycin can change how the body processes this heart medicine, which may increase the risk of dangerous heart rhythm problems.
Clarithromycin carries more major-labeled pairs than Amiodarone
SPL source-record counts only. This page's band is moderate · classes on file: Amiodarone (Class III Antiarrhythmic); Clarithromycin (Macrolide Antibiotic).
Clarithromycin has 16 major-labeled pairs vs Amiodarone's 4. This page itself is in the moderate band, not the major band.
4 major · 9 moderate · 29 minor · 42 total
- Other moderate peers for Amiodarone
- Lithium
- Fluconazole
- Ledipasvir/Sofosbuvir
- Lovastatin
16 major · 35 moderate · 30 minor · 81 total
- Other moderate peers for Clarithromycin
- Omeprazole
- Methylprednisolone
- Sildenafil
- Valproate
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.