Lovastatin and Cyclosporine Interaction
Drug interaction information between Lovastatin and Cyclosporine.
Lovastatin and Cyclosporine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Lovastatin and Cyclosporine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Cyclosporine interferes with how your body handles lovastatin, leading to higher amounts of the drug in your system. This increases the chance of developing severe muscle problems.
FDA Label Information
Gemfibrozil Other fibrates Niacin (nicotinic acid) (≥ 1 g/day) Other Drug Interactions Cyclosporine The risk of myopathy/rhabdomyolysis is increased by concomitant administration of cyclosporine (see WARNINGS , Myopathy/Rhabdomyolysis ).
Lovastatin Also Interacts With
- Darunavir major
- Nirmatrelvir/Ritonavir major
- Spironolactone moderate
- Ketoconazole moderate
- Verapamil moderate
Cyclosporine Also Interacts With
- Clarithromycin major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Pitavastatin major
- Simvastatin major
Frequently Asked Questions
What SPL severity band is on file for Lovastatin + Cyclosporine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cyclosporine has 89 labeled pairs on file vs Lovastatin's 30. In the moderate band specifically: Lovastatin has 17 (also Spironolactone, Ketoconazole, Verapamil, Erythromycin); Cyclosporine has 24 (also Aliskiren, Allopurinol, Amiloride, Amlodipine/Valsartan).
What mechanism field is on file for Lovastatin and Cyclosporine?
Cyclosporine interferes with how your body handles lovastatin, leading to higher amounts of the drug in your system. This increases the chance of developing severe muscle problems.
Cyclosporine carries more major-labeled pairs than Lovastatin
SPL source-record counts only. This page's band is moderate · classes on file: Lovastatin (HMG-CoA Reductase Inhibitor (Statin)); Cyclosporine (Calcineurin Inhibitor (Immunosuppressant)).
Cyclosporine has 5 major-labeled pairs vs Lovastatin's 2. This page itself is in the moderate band, not the major band.
2 major · 17 moderate · 11 minor · 30 total
- Other moderate peers for Lovastatin
- Spironolactone
- Ketoconazole
- Verapamil
- Erythromycin
5 major · 24 moderate · 60 minor · 89 total
- Other moderate peers for Cyclosporine
- Aliskiren
- Allopurinol
- Amiloride
- Amlodipine/Valsartan
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.