Alfuzosin and Itraconazole Interaction
Drug interaction information between Alfuzosin and Itraconazole.
Alfuzosin and Itraconazole have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Alfuzosin and Itraconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Itraconazole slows down the breakdown of alfuzosin in your body, which can lead to an unsafe buildup of the medication. This increases your risk of having a bad reaction to the alfuzosin.
Alfuzosin Also Interacts With
- Ketoconazole major
- Darunavir major
- Nirmatrelvir/Ritonavir major
- Tadalafil minor
Itraconazole Also Interacts With
- Isavuconazonium major
- Lurasidone major
- Pimozide major
- Methadone major
- Midazolam major
Frequently Asked Questions
What SPL severity band is on file for Alfuzosin + Itraconazole?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Itraconazole has 116 labeled pairs on file vs Alfuzosin's 5. In the moderate band specifically: Alfuzosin has 1; Itraconazole has 20 (also Tamsulosin, Rivaroxaban, Tenofovir Disoproxil, Glecaprevir/Pibrentasvir).
What mechanism field is on file for Alfuzosin and Itraconazole?
Itraconazole slows down the breakdown of alfuzosin in your body, which can lead to an unsafe buildup of the medication. This increases your risk of having a bad reaction to the alfuzosin.
Itraconazole carries more major-labeled pairs than Alfuzosin
SPL source-record counts only. This page's band is moderate · classes on file: Alfuzosin (Alpha-1 Blocker (BPH)); Itraconazole (Azole Antifungal).
Itraconazole has 19 major-labeled pairs vs Alfuzosin's 3. This page itself is in the moderate band, not the major band.
3 major · 1 moderate · 1 minor · 5 total
Alfuzosin has no other moderate-band peer in this dataset besides Itraconazole.
19 major · 20 moderate · 77 minor · 116 total
- Other moderate peers for Itraconazole
- Tamsulosin
- Rivaroxaban
- Tenofovir Disoproxil
- Glecaprevir/Pibrentasvir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.