Alfuzosin and Nirmatrelvir/Ritonavir Interaction
Drug interaction information between Alfuzosin and Nirmatrelvir/Ritonavir.
Alfuzosin and Nirmatrelvir/Ritonavir have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Alfuzosin and Nirmatrelvir/Ritonavir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Nirmatrelvir/ritonavir causes alfuzosin to build up in your body by slowing its removal. This can lead to a dangerous drop in your blood pressure.
Alfuzosin Also Interacts With
- Ketoconazole major
- Darunavir major
- Itraconazole moderate
- Tadalafil minor
Nirmatrelvir/Ritonavir Also Interacts With
- Simvastatin major
- Lovastatin major
- Sildenafil major
- Carbamazepine major
- Rifampin major
Frequently Asked Questions
What SPL severity band is on file for Alfuzosin + Nirmatrelvir/Ritonavir?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Nirmatrelvir/Ritonavir has 86 labeled pairs on file vs Alfuzosin's 5. In the major band specifically: Alfuzosin has 3 (also Ketoconazole, Darunavir); Nirmatrelvir/Ritonavir has 23 (also Simvastatin, Lovastatin, Sildenafil, Carbamazepine).
What mechanism field is on file for Alfuzosin and Nirmatrelvir/Ritonavir?
Nirmatrelvir/ritonavir causes alfuzosin to build up in your body by slowing its removal. This can lead to a dangerous drop in your blood pressure.
Nirmatrelvir/Ritonavir carries more major-labeled pairs than Alfuzosin
SPL source-record counts only. This page's band is major · classes on file: Alfuzosin (Alpha-1 Blocker (BPH)); Nirmatrelvir/Ritonavir (Antiviral (Protease Inhibitor Combination)).
Nirmatrelvir/Ritonavir has 23 major-labeled pairs vs Alfuzosin's 3.
3 major · 1 moderate · 1 minor · 5 total
- Other major peers for Alfuzosin
- Ketoconazole
- Darunavir
23 major · 30 moderate · 33 minor · 86 total
- Other major peers for Nirmatrelvir/Ritonavir
- Simvastatin
- Lovastatin
- Sildenafil
- Carbamazepine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.