alfuzosin vs itraconazole
Side-by-side comparison of alfuzosin and itraconazole. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
moderate Known Drug Interaction
Table 1:Drug Interactions with Itraconazole that Affect Concomitant Drug Concentrations Examples of Concomitant Drugs Within Class Prevention or Management Drug Interactions with Itraconazole that Increase Concomitant Drug Concentrations and May Increase Risk of Adverse Reactions Associated with the Concomitant Drug Alpha Blockers Alfuzosin Silodosin Tamsulosin Not recommended during and 2 weeks after itraconazole treatment.
Recommendation: Do not take these medicines together or for two weeks after your itraconazole treatment has ended.
Uroxatral
Sporanox
Alfuzosin is a medicine that helps men with enlarged prostate glands. It relaxes the muscles in the prostate and bladder, making it easier to urinate.
Itraconazole capsules are an antifungal medicine. They treat fungal infections in your body.
This medicine treats the symptoms of benign prostatic hyperplasia (BPH), also known as an enlarged prostate. BPH can cause problems with urination, such as difficulty starting or stopping, frequent urination, and feeling like you can't empty your bladder. Alfuzosin helps to improve these symptoms.
Itraconazole treats fungal infections like blastomycosis, histoplasmosis, and aspergillosis. It can help both people with healthy immune systems and those with weakened immune systems. It also treats onychomycosis, a fungal infection of the toenails or fingernails.
Alfuzosin belongs to a class of drugs called alpha-1 blockers. It works by relaxing the muscles in the prostate and bladder neck. This relaxation allows urine to flow more freely, relieving the symptoms of BPH.
Itraconazole stops fungi from growing. It does this by interfering with the production of a substance fungi need to build their cell membranes. This eventually kills the fungus and clears the infection.
- • Dizziness
- • Upper respiratory tract infection
- • Headache
- • Fatigue
- • Nausea
- • Rash
- • Headache
- Difficulty breathing 89
- The medicine is interacting with another medicine 87
- Tiredness 87
- Sudden damage to the kidneys 79
- Feeling lightheaded or unsteady 74
- Interaction with another medicine 1,118
- Fever 570
- Difficulty breathing 472
- Lung infection 462
- Feeling sick to your stomach 446
Alfuzosin can cause your blood pressure to drop suddenly when you stand up, leading to dizziness or fainting. Be careful when standing up quickly, especially when you first start taking this medicine. If you have chest pain (angina), tell your doctor immediately. This medicine may also affect your heart rhythm. Tell your doctor if you have a history of heart problems.
Itraconazole can cause congestive heart failure. You should not take this medicine if you have heart problems. Itraconazole can also interact with many other medicines. Some of these interactions can be dangerous or even fatal. Check with your doctor about all the medicines you take.
This medicine is only for men and is not intended for use in women. It is not known if alfuzosin can harm an unborn baby or pass into breast milk.
You should not take itraconazole if you are pregnant or plan to become pregnant. It can harm your unborn baby. Talk to your doctor about safe alternatives.
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How to Read This alfuzosin vs itraconazole Comparison
alfuzosin is classified in the Alpha-1 Blocker (BPH) drug class, while itraconazole sits within the Azole Antifungal class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, alfuzosin has 416 submissions while itraconazole has 3,068. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known moderate interaction flagged in FDA labeling, attributed to itraconazole slows down the breakdown of alfuzosin in your body, which can lead to an unsafe buildup of the medication. this increases your risk of having a bad reaction to the alfuzosin.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between alfuzosin and itraconazole - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.