Alfuzosin and Tadalafil Interaction
Drug interaction information between Alfuzosin and Tadalafil.
Alfuzosin and Tadalafil have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Alfuzosin and Tadalafil. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medicines can relax your blood vessels, which may lead to a further drop in blood pressure when taken together.
FDA Label Information
Clinical pharmacology studies have been conducted with coadministration of tadalafil with doxazosin, tamsulosin or alfuzosin.
Alfuzosin Also Interacts With
- Ketoconazole major
- Darunavir major
- Nirmatrelvir/Ritonavir major
- Itraconazole moderate
Tadalafil Also Interacts With
- Hydralazine/Isosorbide Dinitrate major
- Clarithromycin moderate
- Nirmatrelvir/Ritonavir moderate
- Amlodipine minor
- Metoprolol minor
Frequently Asked Questions
What SPL severity band is on file for Alfuzosin + Tadalafil?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Tadalafil has 25 labeled pairs on file vs Alfuzosin's 5. In the minor band specifically: Alfuzosin has 1; Tadalafil has 22 (also Amlodipine, Metoprolol, Tamsulosin, Aspirin).
What mechanism field is on file for Alfuzosin and Tadalafil?
Both of these medicines can relax your blood vessels, which may lead to a further drop in blood pressure when taken together.
Alfuzosin carries more major-labeled pairs than Tadalafil
SPL source-record counts only. This page's band is minor · classes on file: Alfuzosin (Alpha-1 Blocker (BPH)); Tadalafil (PDE5 Inhibitor).
Alfuzosin has 3 major-labeled pairs vs Tadalafil's 1. This page itself is in the minor band, not the major band.
3 major · 1 moderate · 1 minor · 5 total
Alfuzosin has no other minor-band peer in this dataset besides Tadalafil.
1 major · 2 moderate · 22 minor · 25 total
- Other minor peers for Tadalafil
- Amlodipine
- Metoprolol
- Tamsulosin
- Aspirin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.