Alfuzosin and Darunavir Interaction
Drug interaction information between Alfuzosin and Darunavir.
Alfuzosin and Darunavir have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Alfuzosin and Darunavir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Darunavir prevents your body from getting rid of alfuzosin, which can cause the drug to reach high levels and lead to dangerously low blood pressure.
FDA Label Information
Other Agents Alpha 1-adrenoreceptor antagonist: alfuzosin ↑ alfuzosin Co-administration is contraindicated due to potential for serious and/or life-threatening reactions such as hypotension.
Alfuzosin Also Interacts With
- Ketoconazole major
- Nirmatrelvir/Ritonavir major
- Itraconazole moderate
- Tadalafil minor
Darunavir Also Interacts With
- Lovastatin major
- Sildenafil major
- Lurasidone major
- Pimozide major
- Midazolam major
Frequently Asked Questions
What SPL severity band is on file for Alfuzosin + Darunavir?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Darunavir has 101 labeled pairs on file vs Alfuzosin's 5. In the major band specifically: Alfuzosin has 3 (also Ketoconazole, Nirmatrelvir/Ritonavir); Darunavir has 15 (also Lovastatin, Sildenafil, Lurasidone, Pimozide).
What mechanism field is on file for Alfuzosin and Darunavir?
Darunavir prevents your body from getting rid of alfuzosin, which can cause the drug to reach high levels and lead to dangerously low blood pressure.
Darunavir carries more major-labeled pairs than Alfuzosin
SPL source-record counts only. This page's band is major · classes on file: Alfuzosin (Alpha-1 Blocker (BPH)); Darunavir (HIV Protease Inhibitor).
Darunavir has 15 major-labeled pairs vs Alfuzosin's 3.
3 major · 1 moderate · 1 minor · 5 total
- Other major peers for Alfuzosin
- Ketoconazole
- Nirmatrelvir/Ritonavir
15 major · 16 moderate · 70 minor · 101 total
- Other major peers for Darunavir
- Lovastatin
- Sildenafil
- Lurasidone
- Pimozide
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.