What the FDA labels say about taking them together
Alfuzosin and ketoconazole
Alfuzosin's FDA label of December 5, 2024 names ketoconazole in its contraindications section; the ketoconazole label PlainMeds reads does not name alfuzosin. The alfuzosin label: “Drug-Drug Interactions Potent CYP3A4 Inhibitors: UROXATRAL is contraindicated for use with potent CYP3A4 inhibitors since alfuzosin blood levels are increased.”
Check it at the source: the alfuzosin FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.); the ketoconazole FDA label on DailyMed (effective January 28, 2026, E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC).
What does the alfuzosin label say about ketoconazole?
Alfuzosin label, contraindicationsCONTRAINDICATIONS UROXATRAL is contraindicated for use: in patients with moderate or severe hepatic impairment (Childs-Pugh categories B and C), since alfuzosin blood levels are increased in these patients [see Use in Specific Populations (8.7) and Clinical Pharmacology (12.3) ]. with potent CYP3A4 inhibitors such as ketoconazole, itraconazole, and ritonavir, since alfuzosin blood levels are increased [see Drug Interactions (7.1) and Clinical Pharmacology (12.3) ]. …
Alfuzosin label, drug interactionsCYP3A4 Inhibitors UROXATRAL is contraindicated for use with potent CYP3A4 inhibitors such as ketoconazole, itraconazole, or ritonavir, since alfuzosin blood levels are increased [see Contraindications (4), Warnings and Precautions (5.4) and Clinical Pharmacology (12.3) ].
Alfuzosin label, warnings and precautionsDrug-Drug Interactions Potent CYP3A4 Inhibitors: UROXATRAL is contraindicated for use with potent CYP3A4 inhibitors (e.g. ketoconazole, itraconazole, ritonavir) since alfuzosin blood levels are increased [see Contraindications (4), Drug Interactions (7.1) and Clinical Pharmacology (12.3) ].
Source: FDA drug label (Uroxatral), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set 9fc7f119-f36b-44cf-945d-940160f3afe3), via openFDA; the full label on DailyMed
What does the ketoconazole label say about alfuzosin?
Ketoconazole's label (effective January 28, 2026) does not name alfuzosin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (ketoconazole), E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC, effective January 28, 2026 (SPL set cad7c647-34a9-4e4e-83b3-8d78e58f588f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Alfuzosin | Ketoconazole | |
|---|---|---|
| Labeled for | Enlarged prostate (BPH) | Fungal infections |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.105 per tablet 10 mg tablet | $0.249 per gram 2% cream |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once