Alfuzosin and Ketoconazole Interaction
Drug interaction information between Alfuzosin and Ketoconazole.
Alfuzosin and Ketoconazole have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Alfuzosin and Ketoconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Ketoconazole blocks the enzyme that breaks down alfuzosin, which causes the amount of alfuzosin in your blood to rise to unsafe levels.
FDA Label Information
7 DRUG INTERACTIONS Concomitant use of PDE5 inhibitors with alpha adrenergic antagonists, including alfuzosin hydrochloride extended-release tablets, can potentially cause symptomatic hypotension ( 5.4 , 7.4) 7.1 CYP3A4 Inhibitors Alfuzosin hydrochloride extended-release tablets are contraindicated for use with potent CYP3A4 inhibitors such as ketoconazole, itraconazole, or ritonavir, since alfuzosin blood levels are increased [see Contraindications ( 4 ), Warnings and Precautions ( 5.4) and Clinical Pharmacology ( 12.3) ].
Alfuzosin Also Interacts With
- Darunavir major
- Nirmatrelvir/Ritonavir major
- Itraconazole moderate
- Tadalafil minor
Ketoconazole Also Interacts With
- Dronedarone major
- Ranolazine major
- Saxagliptin major
- Sildenafil major
- Theophylline major
Frequently Asked Questions
What SPL severity band is on file for Alfuzosin + Ketoconazole?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ketoconazole has 113 labeled pairs on file vs Alfuzosin's 5. In the major band specifically: Alfuzosin has 3 (also Darunavir, Nirmatrelvir/Ritonavir); Ketoconazole has 6 (also Dronedarone, Ranolazine, Saxagliptin, Sildenafil).
What mechanism field is on file for Alfuzosin and Ketoconazole?
Ketoconazole blocks the enzyme that breaks down alfuzosin, which causes the amount of alfuzosin in your blood to rise to unsafe levels.
Ketoconazole carries more major-labeled pairs than Alfuzosin
SPL source-record counts only. This page's band is major · classes on file: Alfuzosin (Alpha-1 Blocker (BPH)); Ketoconazole (Azole Antifungal).
Ketoconazole has 6 major-labeled pairs vs Alfuzosin's 3.
3 major · 1 moderate · 1 minor · 5 total
- Other major peers for Alfuzosin
- Darunavir
- Nirmatrelvir/Ritonavir
6 major · 22 moderate · 85 minor · 113 total
- Other major peers for Ketoconazole
- Dronedarone
- Ranolazine
- Saxagliptin
- Sildenafil
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.