omadacycline
Brand names: Nuzyra
Nuzyra is an antibiotic medicine. It fights certain bacteria to treat infections.
What it does
Nuzyra treats community-acquired bacterial pneumonia (CABP), a lung infection.
Common side effects
Nausea, Vomiting, Reactions where the IV was given
Key warnings
Nuzyra may cause an imbalance in the number of deaths in patients with pneumonia.
How It Works
Nuzyra is a tetracycline antibiotic. It stops bacteria from growing by interfering with their protein production. This helps your body fight off the infection.
How to Take It
Nuzyra can be given as an IV injection or taken as a pill. For pills, fast for 4 hours before taking it with water. After taking the pill, don't eat or drink anything (except water) for 2 hours. Also, avoid dairy, antacids, and multivitamins for 4 hours after taking the pill. Treatment lasts 7 to 14 days.
Pregnancy & Breastfeeding
Nuzyra can cause tooth discoloration and bone problems in unborn babies. Breastfeeding is not recommended while using Nuzyra.
Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule.
Storage
Store Nuzyra at room temperature, away from moisture and heat. Do not freeze.
Side Effects (from patient reports)
Based on 1,367 FDA adverse event reports.
FDA Adverse Event Report Analysis
Detailed analysis of 1,476 reports from the FDA Adverse Event Reporting System (FAERS). Reports span 2017–2025.
Total Reports
1,476
Death-Related Reports
101
Hospitalization Reports
329
Top Indication
Mycobacterium Abscessus Infection
Gender Distribution
Age Distribution
Most Reported Adverse Reactions (FAERS)
| # | Reaction | Reports |
|---|---|---|
| 1 | OFF LABEL USE | 405 |
| 2 | NAUSEA | 245 |
| 3 | VOMITING | 152 |
| 4 | DRUG INEFFECTIVE | 113 |
| 5 | DIARRHOEA | 107 |
| 6 | INCORRECT PRODUCT ADMINISTRATION DURATION | 76 |
| 7 | RASH | 70 |
| 8 | INCORRECT DOSE ADMINISTERED | 68 |
| 9 | DEATH | 66 |
| 10 | DYSPNOEA | 65 |
| 11 | FATIGUE | 56 |
| 12 | HOSPITALISATION | 55 |
| 13 | HEADACHE | 52 |
| 14 | PRURITUS | 52 |
| 15 | DRUG INEFFECTIVE FOR UNAPPROVED INDICATION | 48 |
Reactions in Death Reports
Reactions in Hospitalization Reports
Source: FDA FAERS (Adverse Event Reporting System) FDA FAERS (Adverse Event Reporting System) Reports are voluntary and do not establish causation
Serious Warnings
Nuzyra may cause an imbalance in the number of deaths in patients with pneumonia. The cause of this is not known, so your doctor will watch you closely. Nuzyra can also cause tooth discoloration and affect bone growth in children under 8 and unborn babies. Diarrhea can occur, so tell your doctor if you have diarrhea while taking Nuzyra.
Known Drug Interactions
( 7.1 ) Absorption of tetracyclines, including NUZYRA, is impaired by antacids containing aluminum, calcium, or magnesium, bismuth subsalicylate and iron containing preparations. 7.2 Antacids and Iron Preparations Absorption of oral tetracyclines, including NUZYRA, is impaired by antacids containing aluminum, calcium, or magnesium, bismuth subsalicylate, and iron containing preparations [see Dosage and Administration (2.1) ].
Mechanism: Bismuth subsalicylate interferes with how your body takes in the antibiotic, making the medicine less effective at fighting infection.
What to do: Avoid taking these two medicines at the same time so the antibiotic can work correctly.
Common Questions
What should I avoid while taking Nuzyra?
Can I take Nuzyra with food?
How long will I need to take Nuzyra?
What if I feel better before finishing all my Nuzyra?
Can Nuzyra affect my teeth?
Can Nuzyra affect my bones?
What should I do if I get diarrhea while taking Nuzyra?
Can I take antacids with Nuzyra?
Will Nuzyra interact with other medications I'm taking?
What happens if I take too much Nuzyra?
What are the common side effects of omadacycline?
Does omadacycline interact with other medications?
What drug class is omadacycline?
Is omadacycline safe during pregnancy?
Related Medications in Tetracycline Antibiotic
Other drugs grouped near omadacycline — same-class peers and common alternatives.
amikacin
Amikin
Amikacin is an antibiotic medicine.
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amoxicillin
Amoxil
Amoxicillin and Clavulanate Potassium is a combination medicine used to fight bacterial infections.
Compare with omadacycline →
amoxicillin/clavulanate
Augmentin
Augmentin is a combination of two medicines, amoxicillin and clavulanate.
Compare with omadacycline →
ampicillin/sulbactam
Unasyn
Unasyn is a combination of two antibiotics that fights bacteria in your body.
Compare with omadacycline →
azithromycin
Zithromax, Z-Pack
Azithromycin is an antibiotic that fights bacteria.
Compare with omadacycline →
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What the FDA Data Shows for omadacycline
The FDA label for omadacycline (sold under brand names such as Nuzyra) classifies it as a prescription-only medication in the Tetracycline Antibiotic class. Nuzyra treats community-acquired bacterial pneumonia (CABP), a lung infection. Official labeling lists 9 commonly reported side effects, including Nausea, Vomiting, Reactions where the IV was given.
Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. For this drug, FAERS contains 1,367 voluntary reports. The database also lists 1 documented drug interaction derived from FDA labeling, with the top-flagged interaction rated minor severity. Acquisition-cost data is surveyed weekly by CMS and updated as manufacturers report changes.
Report counts do not establish causation — a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history, and patent information further shape supply and switching decisions. This page summarizes public FDA data for educational purposes only and is not a substitute for professional medical advice — always consult a licensed healthcare provider before starting, stopping, or changing any medication.
Data Sources
Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS).
FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. Always consult a healthcare professional before making medication decisions.
Last updated: March 31, 2025
Read our methodology — how this data is sourced, computed, and verified.
All federal data sources used on this page
- FDA Orange Book — approved drug products with therapeutic equivalence. accessdata.fda.gov/cder/ob
- FDA DailyMed — NIH-hosted drug labeling for FDA-approved meds. dailymed.nlm.nih.gov
- FDA Adverse Event Reporting System (FAERS) — post-marketing safety surveillance. fda.gov/drugs/faers
- NLM RxNorm — standardized clinical drug nomenclature. nlm.nih.gov/research/umls/rxnorm
- CMS Medicare Part B Drug Average Sales Price Files — federal drug pricing data. cms.gov/medicare/part-b-drugs/asp
- FDA Drug Shortages Database — current and resolved drug shortage tracking. accessdata.fda.gov/drugshortages