Prescription medication · Tetracycline Antibiotic
omadacycline
Also sold as Nuzyra. Nuzyra treats community-acquired bacterial pneumonia (CABP), a lung infection.
Data updated 2026-05-15
- 1,476
- FDA reportsRarely reported
- 1
- InteractionFew interactions
- Rx
- Availability
What the data shows
omadacycline (Nuzyra) is a prescription Tetracycline Antibiotic, among the least-reported drugs the FDA tracks (1,476 FDA reports), with 1 documented drug interaction.
Reporting volume reflects how widely a drug is used and studied, not how dangerous it is, a FAERS report documents a temporal association, never proof of cause.
omadacycline (Nuzyra) is a prescription Tetracycline Antibiotic. Nuzyra treats community-acquired bacterial pneumonia (CABP), a lung infection.
Nuzyra is an antibiotic medicine. It fights certain bacteria to treat infections.
Verify with FDA → · CMS NADAC pricing →
What it does
Nuzyra treats community-acquired bacterial pneumonia (CABP), a lung infection.
Common side effects
Nausea, Vomiting, Reactions where the IV was given
Key warnings
Nuzyra may cause an imbalance in the number of deaths in patients with pneumonia.
The sections below are summarized in plain English from omadacycline's FDA-approved prescribing information. They describe what the official label says, and are not personal medical advice.
How It Works
Nuzyra is a tetracycline antibiotic. It stops bacteria from growing by interfering with their protein production. This helps your body fight off the infection.
Side Effects (from patient reports)
Based on 1,476 FDA adverse event reports.
Most-reported reactions
Adverse reactions in FAERS for omadacycline, by number of reports
- Nausea
Nausea
245 reports
- Vomiting
Vomiting
152 reports
- Diarrhoea
Diarrhoea
107 reports
- Incorrect Product Administration Duration 76
Incorrect Product Administration Duration
76 reports
- Rash 70
Rash
70 reports
- Incorrect Dose Administered 68
Incorrect Dose Administered
68 reports
- Death 66
Death
66 reports
- Dyspnoea 65
Dyspnoea
65 reports
- Fatigue 56
Fatigue
56 reports
- Hospitalisation 55
Hospitalisation
55 reports
What this shows Bars show how often each reaction was reported, not how likely it is to happen, a report records a temporal association, never proof that the drug caused it.
Reports over time
Adverse-event reports filed for omadacycline each year to the FDA Adverse Event Reporting System (FAERS).
Year-to-year volume tracks usage, prescribing, and scrutiny, not a change in per-patient risk. Source: FDA FAERS.
Where omadacycline sits
omadacycline has more FDA adverse-event reports than 9% of the drugs FAERS tracks. A high position reflects how widely a drug is used and watched, not how dangerous it is.
Percentile across all drugs PlainMeds tracks by FAERS report volume. The dot is omadacycline; the line is the median (50th percentile).
FDA Adverse Event Report Analysis
Detailed analysis of 1,476 reports from the FDA Adverse Event Reporting System (FAERS). Reports span 2017–2025.
Total Reports
1,476
Reports Mentioning Death
101
6.8% of reports — not proof of cause
Hospitalization Reports
329
Top Indication
Mycobacterium Abscessus Infection
Gender Distribution
Age Distribution
Most Reported Adverse Reactions (FAERS)
| # | Reaction | Reports |
|---|---|---|
| 2 | NAUSEA | 245 |
| 3 | VOMITING | 152 |
| 5 | DIARRHOEA | 107 |
| 6 | INCORRECT PRODUCT ADMINISTRATION DURATION | 76 |
| 7 | RASH | 70 |
| 8 | INCORRECT DOSE ADMINISTERED | 68 |
| 9 | DEATH | 66 |
| 10 | DYSPNOEA | 65 |
| 11 | FATIGUE | 56 |
| 12 | HOSPITALISATION | 55 |
| 13 | HEADACHE | 52 |
| 14 | PRURITUS | 52 |
| 15 | DRUG INEFFECTIVE FOR UNAPPROVED INDICATION | 48 |
| 16 | COUGH | 44 |
| 18 | ASPARTATE AMINOTRANSFERASE INCREASED | 41 |
Reactions in Death Reports
Reactions in Hospitalization Reports
Source: FDA FAERS (Adverse Event Reporting System) Reports are voluntary and do not establish causation
Serious Warnings
Nuzyra may cause an imbalance in the number of deaths in patients with pneumonia. The cause of this is not known, so your doctor will watch you closely. Nuzyra can also cause tooth discoloration and affect bone growth in children under 8 and unborn babies. Diarrhea can occur, so tell your doctor if you have diarrhea while taking Nuzyra.
Known Drug Interactions
( 7.1 ) Absorption of tetracyclines, including NUZYRA, is impaired by antacids containing aluminum, calcium, or magnesium, bismuth subsalicylate and iron containing preparations. 7.2 Antacids and Iron Preparations Absorption of oral tetracyclines, including NUZYRA, is impaired by antacids containing aluminum, calcium, or magnesium, bismuth subsalicylate, and iron containing preparations [see Dosage and Administration (2.1) ].
Mechanism: Bismuth subsalicylate interferes with how your body takes in the antibiotic, making the medicine less effective at fighting infection.
This is a plain-language summary of FDA-label interaction records and does not provide individual medication-combination directions.
Common Questions
What should I avoid while taking Nuzyra?
Can I take Nuzyra with food?
How long will I need to take Nuzyra?
What if I feel better before finishing all my Nuzyra?
Can Nuzyra affect my teeth?
Can Nuzyra affect my bones?
What should I do if I get diarrhea while taking Nuzyra?
Can I take antacids with Nuzyra?
Will Nuzyra interact with other medications I'm taking?
What happens if I take too much Nuzyra?
What are the common side effects of omadacycline?
Does omadacycline interact with other medications?
What drug class is omadacycline?
What pregnancy or breastfeeding source fields are listed for omadacycline?
Related Medications in Tetracycline Antibiotic
Other drugs grouped near omadacycline - same-class peers and common alternatives.
amikacin
Amikin
Amikacin is an antibiotic medicine.
Compare with omadacycline →
amoxicillin
Amoxil
Amoxicillin and Clavulanate Potassium is a combination medicine used to fight bacterial infections.
Compare with omadacycline →
amoxicillin/clavulanate
Augmentin
Augmentin is a combination of two medicines, amoxicillin and clavulanate.
Compare with omadacycline →
ampicillin/sulbactam
Unasyn
Unasyn is a combination of two antibiotics that fights bacteria in your body.
Compare with omadacycline →
azithromycin
Zithromax, Z-Pack
Azithromycin is an antibiotic that fights bacteria.
Compare with omadacycline →
Compare beyond drug class
Nationwide peers by FAERS volume & death-report share
Two PlainMeds-derived comparison paths for omadacycline: nearest FDA FAERS report volume and nearest death-report share among drugs with at least 1,000 logged reports, excluding same-class neighbors listed above. Counts reflect reporting volume, not proven individual harm.
Similar FAERS report volume
Nearest drugs by total FAERS reports. This record: 1,476.
Similar death-report share
Nearest drugs by FAERS death-report share. This record: 6.84%.
- buspirone Δ 0.06 pts · 10,228 reports · Azapirone Anxiolytic 6.79%death share
- anastrozole Δ 0.07 pts · 35,161 reports · Aromatase Inhibitor 6.78%death share
- ziprasidone Δ 0.08 pts · 17,328 reports · Atypical Antipsychotic 6.76%death share
- oxcarbazepine Δ 0.11 pts · 31,347 reports · Anticonvulsant 6.73%death share
Medication Guides
Understanding Drug Interactions
How CYP450 enzymes, inhibitors, and inducers affect your medications
Generic vs Brand Name Drugs
FDA requirements, cost savings, and when the difference matters
Narrow Therapeutic Index Drugs
FDA bioequivalence and label-record context for narrow therapeutic index medicines
Common Drug Interactions
Dangerous medication combinations and how to protect yourself
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What the FDA Data Shows for omadacycline
The FDA label for omadacycline (sold under brand names such as Nuzyra) classifies it as a prescription-only medication in the Tetracycline Antibiotic class. Nuzyra treats community-acquired bacterial pneumonia (CABP), a lung infection. Official labeling lists 9 commonly reported side effects, including Nausea, Vomiting, Reactions where the IV was given.
Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. For this drug, FAERS contains 1,476 voluntary reports. The database also lists 1 documented drug interaction derived from FDA labeling, with the top-flagged interaction rated minor severity. Acquisition-cost data is surveyed weekly by CMS and updated as manufacturers report changes.
Report counts do not establish causation, a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history, and patent information are separate source-record fields. This page is a public FDA/CMS registry and does not provide medical, treatment, substitution, or medication-change directions.
Data Sources
Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS).
FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. This registry does not provide medication decisions.
Last updated: March 31, 2025
PlainMeds is rendered directly from FDA openFDA/FAERS extracts, DailyMed labels, and CMS drug-pricing files, no number is typed in by an editor. FAERS counts, recalls, shortages, and price figures on this page are queried live from those federal extracts. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error. Data current as of 2026-05-15. Primary sources: openFDA / FAERS, DailyMed and CMS Part B ASP.
Read our methodology - how this data is sourced, computed, and verified.
Data currency: FDA FAERS adverse-event reports through 2025, CMS NADAC acquisition-cost pricing effective December 2024, compiled from the source snapshot dated . See our methodology for per-source dates and refresh cadence. Spot a figure that looks wrong? Report a data issue.
All federal data sources used on this page
- FDA Orange Book - approved drug products with therapeutic equivalence. accessdata.fda.gov/cder/ob
- FDA DailyMed - NIH-hosted drug labeling for FDA-approved meds. dailymed.nlm.nih.gov
- FDA Adverse Event Reporting System (FAERS) - post-marketing safety surveillance. fda.gov/drugs/faers
- NLM RxNorm - standardized clinical drug nomenclature. nlm.nih.gov/research/umls/rxnorm
- CMS Medicare Part B Drug Average Sales Price Files - federal drug pricing data. cms.gov/medicare/part-b-drugs/asp
- FDA Drug Shortages Database - current and resolved drug shortage tracking. accessdata.fda.gov/drugshortages