Prescription medication · Carbapenem / Beta-Lactamase Inhibitor
meropenem/vaborbactam
Also sold as Vabomere. Vabomere treats complicated urinary tract infections (cUTIs) in adults.
Data updated 2026-05-15
- 13,049
- FDA reports
- 2
- InteractionsFew interactions
- Rx
- Availability
What the data shows
meropenem/vaborbactam (Vabomere) is a prescription Carbapenem / Beta-Lactamase Inhibitor, with 13,049 FDA adverse-event reports on file, with 2 documented drug interactions.
Reporting volume reflects how widely a drug is used and studied, not how dangerous it is, a FAERS report documents a temporal association, never proof of cause.
meropenem/vaborbactam (Vabomere) is a prescription Carbapenem / Beta-Lactamase Inhibitor. Vabomere treats complicated urinary tract infections (cUTIs) in adults.
Vabomere is a drug that combines two medicines to fight certain infections. It contains meropenem, an antibacterial, and vaborbactam, which helps meropenem work better.
Verify with FDA → · CMS NADAC pricing →
What it does
Vabomere treats complicated urinary tract infections (cUTIs) in adults.
Common side effects
Headache, Irritation, swelling, or pain at the IV site, Diarrhea
Key warnings
You should not take this medicine if you are allergic to any of its ingredients or to similar drugs.
The sections below are summarized in plain English from meropenem/vaborbactam's FDA-approved prescribing information. They describe what the official label says, and are not personal medical advice.
How It Works
Meropenem kills bacteria by stopping them from building cell walls. Vaborbactam blocks enzymes that bacteria use to break down meropenem. This helps meropenem work more effectively against the infection.
Side Effects (from patient reports)
Based on 13,049 FDA adverse event reports.
Most-reported reactions
Adverse reactions in FAERS for meropenem/vaborbactam, by number of reports
- Pyrexia
Pyrexia
2,090 reports
- Pneumonia
Pneumonia
1,435 reports
- Sepsis
Sepsis
1,364 reports
- Septic Shock
Septic Shock
1,353 reports
- Multiple Organ Dysfunction Syndrome
Multiple Organ Dysfunction Syndrome
1,220 reports
- Acute Kidney Injury
Acute Kidney Injury
1,212 reports
- Condition Aggravated
Condition Aggravated
1,145 reports
- Respiratory Failure
Respiratory Failure
1,083 reports
- Thrombocytopenia
Thrombocytopenia
1,075 reports
- Febrile Neutropenia
Febrile Neutropenia
1,072 reports
What this shows Bars show how often each reaction was reported, not how likely it is to happen, a report records a temporal association, never proof that the drug caused it.
Serious Warnings
You should not take this medicine if you are allergic to any of its ingredients or to similar drugs. Vabomere may cause seizures, especially if you have kidney problems or a history of seizures. It can also cause severe muscle damage called rhabdomyolysis. Diarrhea can occur, and it may be a sign of a serious infection in your colon.
Known Drug Interactions
7.2 Probenecid Probenecid competes with meropenem for active tubular secretion, resulting in increased plasma concentrations of meropenem. Co-administration of probenecid with VABOMERE is not recommended [see Clinical Pharmacology (12.3) ].
Mechanism: Probenecid blocks the kidneys from removing meropenem, which makes the level of the antibiotic in your blood go up.
( 7.4 , 12.3 ) 7.1 Valproic Acid Case reports in the literature have shown that co-administration of carbapenems, including meropenem, to patients receiving valproic acid or divalproex sodium results in a reduction in valproic acid concentrations. 7.2 Probenecid Probenecid competes with meropenem for active tubular secretion, resulting in increased plasma concentrations of meropenem.
Mechanism: Meropenem can significantly lower the amount of seizure medication in your blood, which increases the risk of having a seizure.
This is a plain-language summary of FDA-label interaction records and does not provide individual medication-combination directions.
Common Questions
What should I tell my doctor before taking Vabomere?
Can Vabomere interact with other medications?
What if I experience side effects while taking Vabomere?
Will Vabomere definitely cure my infection?
How will I know if Vabomere is working?
Can I take Vabomere orally?
What happens if my kidney function is not normal?
Can I drive or operate machinery while taking Vabomere?
What kind of birth control should I use while taking Vabomere?
How long will I need to stay in the hospital to receive Vabomere?
What are the common side effects of meropenem/vaborbactam?
Does meropenem/vaborbactam interact with other medications?
What drug class is meropenem/vaborbactam?
What pregnancy or breastfeeding source fields are listed for meropenem/vaborbactam?
Related Medications in Carbapenem / Beta-Lactamase Inhibitor
Other drugs grouped near meropenem/vaborbactam - same-class peers and common alternatives.
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Amoxil
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amoxicillin/clavulanate
Augmentin
Augmentin is a combination of two medicines, amoxicillin and clavulanate.
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ampicillin/sulbactam
Unasyn
Unasyn is a combination of two antibiotics that fights bacteria in your body.
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azithromycin
Zithromax, Z-Pack
Azithromycin is an antibiotic that fights bacteria.
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Medication Guides
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Common Drug Interactions
Dangerous medication combinations and how to protect yourself
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What the FDA Data Shows for meropenem/vaborbactam
The FDA label for meropenem/vaborbactam (sold under brand names such as Vabomere) classifies it as a prescription-only medication in the Carbapenem / Beta-Lactamase Inhibitor class. Vabomere treats complicated urinary tract infections (cUTIs) in adults. Official labeling lists 3 commonly reported side effects, including Headache, Irritation, swelling, or pain at the IV site, Diarrhea.
Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. For this drug, FAERS contains 13,049 voluntary reports. The database also lists 2 documented drug interactions derived from FDA labeling, with the top-flagged interaction rated moderate severity. Acquisition-cost data is surveyed weekly by CMS and updated as manufacturers report changes.
Report counts do not establish causation, a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history, and patent information are separate source-record fields. This page is a public FDA/CMS registry and does not provide medical, treatment, substitution, or medication-change directions.
Data Sources
Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS).
FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. This registry does not provide medication decisions.
Last updated: March 25, 2025
PlainMeds is rendered directly from FDA openFDA/FAERS extracts, DailyMed labels, and CMS drug-pricing files, no number is typed in by an editor. FAERS counts, recalls, shortages, and price figures on this page are queried live from those federal extracts. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error. Data current as of 2026-05-15. Primary sources: openFDA / FAERS, DailyMed and CMS Part B ASP.
Read our methodology - how this data is sourced, computed, and verified.
Data currency: FDA FAERS adverse-event reports through 2025, CMS NADAC acquisition-cost pricing effective December 2024, compiled from the source snapshot dated . See our methodology for per-source dates and refresh cadence. Spot a figure that looks wrong? Report a data issue.
All federal data sources used on this page
- FDA Orange Book - approved drug products with therapeutic equivalence. accessdata.fda.gov/cder/ob
- FDA DailyMed - NIH-hosted drug labeling for FDA-approved meds. dailymed.nlm.nih.gov
- FDA Adverse Event Reporting System (FAERS) - post-marketing safety surveillance. fda.gov/drugs/faers
- NLM RxNorm - standardized clinical drug nomenclature. nlm.nih.gov/research/umls/rxnorm
- CMS Medicare Part B Drug Average Sales Price Files - federal drug pricing data. cms.gov/medicare/part-b-drugs/asp
- FDA Drug Shortages Database - current and resolved drug shortage tracking. accessdata.fda.gov/drugshortages