Prescription medicine
Isoflurane Brand names: Forane, Terrell
Isoflurane (Terrell) is a prescription medicine with an FDA approval on record since 1979. FDA's NDC Directory lists it from 5 generic labelers.
- Generic listed
Check it at the source: the isoflurane FDA label on DailyMed (effective January 5, 2026, Shandong New Time Pharmaceutical Co., Ltd.); the NDA 17624 record on Drugs@FDA; every isoflurane label on DailyMed.
Highlights of the record
FDA label of January 5, 2026; NDC Directory, Drugs@FDA and Orange Book, October 8, 2026
Used for
From the label: indications and usageIsoflurane, USP liquid for inhalation may be used for induction and maintenance of general anesthesia.
Forms and strengths
- 1 ml/ml
- 100 ml/100ml
- 250 ml/250ml
Liquid; inhalant.
On the market
- Earliest approval on file
- December 18, 1979 Forane, Baxter Hlthcare; Drugs@FDA’s file, where older or withdrawn approvals can be missing
- Generic approvals
- 6 first January 25, 1993; 4 with a marketed status in Drugs@FDA
- Labelers listed (NDC)
- 6 of which 5 under generic applications, 1 under brand applications, repackagers included
Supply and safety
- Pharmacy cost (NADAC)
- Not in the survey
- Shortage (FDA)
- No current entry
- Recalls by its makers (FDA)
- No recall recorded
- FAERS reports
- 1,935 through July 30, 2026
What is isoflurane used for?
From the label: indications and usageIsoflurane, USP liquid for inhalation may be used for induction and maintenance of general anesthesia. Adequate data have not been developed to establish its application in obstetrical anesthesia. Isoflurane, USP liquid for inhalation, a general anesthetic, is an inhalation agent indicated for induction and maintenance of general anesthesia.
FDA pharmacologic class: General Anesthetic.
Source: FDA drug label (Isoflurane), Shandong New Time Pharmaceutical Co., Ltd., effective January 5, 2026 (SPL set 662ceaf6-650b-4dea-bbee-652f46426024), via openFDA; the full label on DailyMed
Is there a generic for isoflurane (Terrell)?
The FDA approved the first generic isoflurane on January 25, 1993. 6 generic applications are approved; 4 of them carry a current (not discontinued) marketing status in Drugs@FDA; that status is not evidence that the generic is on sale.
FDA's NDC Directory lists isoflurane from 5 labelers under a generic (ANDA) application and from 1 brand labeler. A listing means the company has registered the product for sale; it does not show that every pharmacy stocks it.
- 1979 earliest approval on file
- 1993 first generic approved
Source: Drugs@FDA, FDA NDC Directory and the Orange Book (openFDA bulk files, October 8, 2026)
What does the isoflurane label say about other medicines?
The isoflurane label names 8 other medicines in its interaction, contraindication or warning sections. The labels of 12 other medicines name isoflurane. The sentences are the labels' own; a label lists what its studies and reports found, not every interaction.
| Medicine named | Section | What the label says |
|---|---|---|
| Atracurium | drug interactions | In general, anesthetic concentrations of isoflurane at equilibrium reduce the ED 95 of succinylcholine, atracurium, pancuronium, rocuronium and vecuronium by approximately 25 to 40% or more compared to N 2 O/opioid anesthesia. |
| Dantrolene | warnings and precautions | Discontinue triggering agents, administer intravenous dantrolene sodium, and apply supportive therapies. |
| Fentanyl | drug interactions | Opioids such as fentanyl and its analogues, when combined with isoflurane, may lead to a synergistic fall in blood pressure and respiratory rate. |
| Nitrous oxide | drug interactions | Nitrous oxide decreases the MAC of isoflurane [see Dosage and Administration (2.1)]. |
| Rocuronium | drug interactions | In general, anesthetic concentrations of isoflurane at equilibrium reduce the ED 95 of succinylcholine, atracurium, pancuronium, rocuronium and vecuronium by approximately 25 to 40% or more compared to N 2 O/opioid anesthesia. |
| Sevoflurane | drug interactions | Isoflurane is similar to sevoflurane in the sensitization of the myocardium to arrhythmogenic effect of exogenously administered adrenaline. |
| Succinylcholine | drug interactions | In general, anesthetic concentrations of isoflurane at equilibrium reduce the ED 95 of succinylcholine, atracurium, pancuronium, rocuronium and vecuronium by approximately 25 to 40% or more compared to N 2 O/opioid anesthesia. |
| Vecuronium | drug interactions | In general, anesthetic concentrations of isoflurane at equilibrium reduce the ED 95 of succinylcholine, atracurium, pancuronium, rocuronium and vecuronium by approximately 25 to 40% or more compared to N 2 O/opioid anesthesia. |
Other labels that name isoflurane
Source: FDA drug label (Isoflurane), Shandong New Time Pharmaceutical Co., Ltd., effective January 5, 2026 (SPL set 662ceaf6-650b-4dea-bbee-652f46426024), via openFDA; the full label on DailyMed
What do FAERS reports show for isoflurane?
The FDA Adverse Event Reporting System holds 1,935 reports that list isoflurane among the medicines taken, through July 30, 2026, each a report of something that happened, not proof the medicine caused it; 299 are coded as a death and 742 as a hospital stay. Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.
Reports received each year
The most reported reactions
Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026
What next?
- Other general anesthetics
- the pharmacologic class, with prices and generics
- Isoflurane side effects
- the label's list beside FAERS reports
- Check an interaction
- what two or more labels say about each other