Ziprasidone and Lorazepam Interaction
Drug interaction information between Ziprasidone and Lorazepam.
Ziprasidone and Lorazepam have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Ziprasidone and Lorazepam. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These medications do not interfere with each other's levels in the bloodstream or how the body clears them. They are processed by the body independently without interaction.
FDA Label Information
7.9 Other Concomitant Drug Therapy Population pharmacokinetic analysis of schizophrenic patients enrolled in controlled clinical trials has not revealed evidence of any clinically significant pharmacokinetic interactions with benztropine, propranolol, or lorazepam.
Ziprasidone Also Interacts With
- Buspirone moderate
- Lithium moderate
- Tetrabenazine moderate
- Estradiol minor
- Propranolol minor
Lorazepam Also Interacts With
- Valproate minor
- Clozapine minor
- Probenecid minor
- Theophylline minor
- Aripiprazole minor
Frequently Asked Questions
What SPL severity band is on file for Ziprasidone + Lorazepam?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ziprasidone has 18 labeled pairs on file vs Lorazepam's 11. In the minor band specifically: Ziprasidone has 15 (also Estradiol, Propranolol, Progesterone, Ketoconazole); Lorazepam has 11 (also Valproate, Clozapine, Probenecid, Theophylline).
What mechanism field is on file for Ziprasidone and Lorazepam?
These medications do not interfere with each other's levels in the bloodstream or how the body clears them. They are processed by the body independently without interaction.
Ziprasidone's labeled portfolio outnumbers Lorazepam
SPL source-record counts only. This page's band is minor · classes on file: Ziprasidone (Atypical Antipsychotic); Lorazepam (Benzodiazepine).
0 major · 3 moderate · 15 minor · 18 total
- Other minor peers for Ziprasidone
- Estradiol
- Propranolol
- Progesterone
- Ketoconazole
0 major · 0 moderate · 11 minor · 11 total
- Other minor peers for Lorazepam
- Valproate
- Clozapine
- Probenecid
- Theophylline
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.