Ziprasidone and Ketoconazole Interaction
Drug interaction information between Ziprasidone and Ketoconazole.
Ziprasidone and Ketoconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Ziprasidone and Ketoconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Ketoconazole blocks the enzyme that breaks down ziprasidone, which causes the levels of ziprasidone in your body to rise.
FDA Label Information
Ketoconazole Ketoconazole, a potent inhibitor of CYP3A4, at a dose of 400 mg QD for 5 days, increased the AUC and C max of ziprasidone by about 35 to 40%.
Ziprasidone Also Interacts With
- Buspirone moderate
- Lithium moderate
- Tetrabenazine moderate
- Estradiol minor
- Propranolol minor
Ketoconazole Also Interacts With
- Alfuzosin major
- Dronedarone major
- Ranolazine major
- Saxagliptin major
- Sildenafil major
Frequently Asked Questions
What SPL severity band is on file for Ziprasidone + Ketoconazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ketoconazole has 113 labeled pairs on file vs Ziprasidone's 18. In the minor band specifically: Ziprasidone has 15 (also Estradiol, Propranolol, Lorazepam, Progesterone); Ketoconazole has 85 (also Abiraterone, Acetaminophen/Oxycodone, Alosetron, Amphotericin B).
What mechanism field is on file for Ziprasidone and Ketoconazole?
Ketoconazole blocks the enzyme that breaks down ziprasidone, which causes the levels of ziprasidone in your body to rise.
Ketoconazole carries more major-labeled pairs than Ziprasidone
SPL source-record counts only. This page's band is minor · classes on file: Ziprasidone (Atypical Antipsychotic); Ketoconazole (Azole Antifungal).
Ketoconazole has 6 major-labeled pairs vs Ziprasidone's 0. This page itself is in the minor band, not the major band.
0 major · 3 moderate · 15 minor · 18 total
- Other minor peers for Ziprasidone
- Estradiol
- Propranolol
- Lorazepam
- Progesterone
6 major · 22 moderate · 85 minor · 113 total
- Other minor peers for Ketoconazole
- Abiraterone
- Acetaminophen/Oxycodone
- Alosetron
- Amphotericin B
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.