Ziprasidone and Lithium Interaction
Drug interaction information between Ziprasidone and Lithium.
Ziprasidone and Lithium have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Ziprasidone and Lithium. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
These drugs can both raise serotonin levels in the body. When used together, they may cause a serious reaction called serotonin syndrome.
What To Do
Your doctor should monitor you for symptoms like muscle stiffness or fever. Do not stop taking your medicine without talking to your provider first.
FDA Label Information
Risk of serotonin syndrome with concomitant therapy with other serotonergic drugs such as SNRIs, SSRIs, triptans, tricyclic antidepressants, opioids, lithium, tryptophan, buspirone, amphetamines, and St. 7.5 Lithium Ziprasidone at a dose of 40 mg twice daily administered concomitantly with lithium at a dose of 450 mg twice daily for 7 days did not affect the steady-state level or renal clearance of lithium. Ziprasidone dosed adjunctively to lithium in a maintenance trial of bipolar patients did not affect mean therapeutic lithium levels.
Ziprasidone Also Interacts With
- Buspirone moderate
- Tetrabenazine moderate
- Estradiol minor
- Propranolol minor
- Lorazepam minor
Lithium Also Interacts With
- Amlodipine/Benazepril major
- Risperidone major
- Amiloride moderate
- Amiodarone moderate
- Amlodipine/Valsartan moderate
Frequently Asked Questions
Can I take Ziprasidone and Lithium together?
This is a moderate interaction. Your doctor should monitor you for symptoms like muscle stiffness or fever. Do not stop taking your medicine without talking to your provider first.
How serious is the interaction between Ziprasidone and Lithium?
This interaction is classified as "moderate" severity by the FDA. Moderate interactions may worsen your condition or change how your medications work.
Why do Ziprasidone and Lithium interact?
These drugs can both raise serotonin levels in the body. When used together, they may cause a serious reaction called serotonin syndrome.
Understanding the Ziprasidone and Lithium Interaction
FDA-approved prescribing information for these two drugs flags their combination as a moderate-severity interaction. Ziprasidone belongs to the Atypical Antipsychotic class and Lithium belongs to the Mood Stabilizer class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: These drugs can both raise serotonin levels in the body. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Ziprasidone has 18 total documented interactions on file in this dataset, and Lithium has 90. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor should monitor you for symptoms like muscle stiffness or fever. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Ziprasidone or Lithium based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.