Ziprasidone and Lithium Interaction
Drug interaction information between Ziprasidone and Lithium.
Ziprasidone and Lithium have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Ziprasidone and Lithium. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These drugs can both raise serotonin levels in the body. When used together, they may cause a serious reaction called serotonin syndrome.
FDA Label Information
Risk of serotonin syndrome with concomitant therapy with other serotonergic drugs such as SNRIs, SSRIs, triptans, tricyclic antidepressants, opioids, lithium, tryptophan, buspirone, amphetamines, and St. 7.5 Lithium Ziprasidone at a dose of 40 mg twice daily administered concomitantly with lithium at a dose of 450 mg twice daily for 7 days did not affect the steady-state level or renal clearance of lithium. Ziprasidone dosed adjunctively to lithium in a maintenance trial of bipolar patients did not affect mean therapeutic lithium levels.
Ziprasidone Also Interacts With
- Buspirone moderate
- Tetrabenazine moderate
- Estradiol minor
- Propranolol minor
- Lorazepam minor
Lithium Also Interacts With
- Amlodipine/Benazepril major
- Risperidone major
- Amiloride moderate
- Amiodarone moderate
- Amlodipine/Valsartan moderate
Frequently Asked Questions
What SPL severity band is on file for Ziprasidone + Lithium?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lithium has 90 labeled pairs on file vs Ziprasidone's 18. In the moderate band specifically: Ziprasidone has 3 (also Buspirone, Tetrabenazine); Lithium has 23 (also Amiloride, Amiodarone, Amlodipine/Valsartan, Azilsartan).
What mechanism field is on file for Ziprasidone and Lithium?
These drugs can both raise serotonin levels in the body. When used together, they may cause a serious reaction called serotonin syndrome.
Lithium carries more major-labeled pairs than Ziprasidone
SPL source-record counts only. This page's band is moderate · classes on file: Ziprasidone (Atypical Antipsychotic); Lithium (Mood Stabilizer).
Lithium has 2 major-labeled pairs vs Ziprasidone's 0. This page itself is in the moderate band, not the major band.
0 major · 3 moderate · 15 minor · 18 total
- Other moderate peers for Ziprasidone
- Buspirone
- Tetrabenazine
2 major · 23 moderate · 65 minor · 90 total
- Other moderate peers for Lithium
- Amiloride
- Amiodarone
- Amlodipine/Valsartan
- Azilsartan
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.