Ziprasidone and Buspirone Interaction
Drug interaction information between Ziprasidone and Buspirone.
Ziprasidone and Buspirone have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Ziprasidone and Buspirone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these drugs increase a chemical in the brain called serotonin. Having too much serotonin can lead to a dangerous condition called serotonin syndrome.
FDA Label Information
Risk of serotonin syndrome with concomitant therapy with other serotonergic drugs such as SNRIs, SSRIs, triptans, tricyclic antidepressants, opioids, lithium, tryptophan, buspirone, amphetamines, and St.
Ziprasidone Also Interacts With
- Lithium moderate
- Tetrabenazine moderate
- Estradiol minor
- Propranolol minor
- Lorazepam minor
Buspirone Also Interacts With
- Tranylcypromine moderate
- Citalopram minor
- Darunavir minor
- Desvenlafaxine minor
- Diltiazem minor
Frequently Asked Questions
What SPL severity band is on file for Ziprasidone + Buspirone?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ziprasidone has 18 labeled pairs on file vs Buspirone's 17. In the moderate band specifically: Ziprasidone has 3 (also Lithium, Tetrabenazine); Buspirone has 2 (also Tranylcypromine).
What mechanism field is on file for Ziprasidone and Buspirone?
Both of these drugs increase a chemical in the brain called serotonin. Having too much serotonin can lead to a dangerous condition called serotonin syndrome.
Ziprasidone's labeled portfolio outnumbers Buspirone
SPL source-record counts only. This page's band is moderate · classes on file: Ziprasidone (Atypical Antipsychotic); Buspirone (Azapirone Anxiolytic).
0 major · 3 moderate · 15 minor · 18 total
- Other moderate peers for Ziprasidone
- Lithium
- Tetrabenazine
0 major · 2 moderate · 15 minor · 17 total
- Other moderate peers for Buspirone
- Tranylcypromine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.