What the FDA labels say about taking them together
Lorazepam and valproic acid
Valproic acid's FDA label of January 24, 2025 names lorazepam in its drug interactions section; the lorazepam labels PlainMeds reads (3) do not name valproic acid. The valproic acid label: “Lorazepam Concomitant administration of valproate (500 mg BID) and lorazepam (1 mg BID) in normal male volunteers (n = 9) was accompanied by a 17% decrease in the plasma clearance of lorazepam.”
Check it at the source: the lorazepam FDA label on DailyMed (effective July 9, 2025, Bausch Health US LLC); the valproic acid FDA label on DailyMed (effective January 24, 2025, PAI Holdings, LLC dba PAI Pharma).
What does the lorazepam label say about valproic acid?
Lorazepam's label (effective July 9, 2025) and its 2 other brand-application labels do not name valproic acid in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Ativan), Bausch Health US LLC, effective July 9, 2025 (SPL set 89057c93-8155-4040-acec-64e877bd2b4c), via openFDA; the full label on DailyMed
What does the valproic acid label say about lorazepam?
Valproic acid label, drug interactionsLorazepam Concomitant administration of valproate (500 mg BID) and lorazepam (1 mg BID) in normal male volunteers (n = 9) was accompanied by a 17% decrease in the plasma clearance of lorazepam.
Source: FDA drug label (VALPROIC ACID), PAI Holdings, LLC dba PAI Pharma, effective January 24, 2025 (SPL set 7d5cb52e-37dd-4dfa-a6f4-09f9548846c6), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Lorazepam | Valproic acid | |
|---|---|---|
| Labeled for | Anxiety | Seizures and epilepsy, Migraine |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0344 per tablet 0.5 mg tablet | $0.243 per capsule 250 mg capsule |
| Shortage now | In shortage | Listed; available |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once