Ziprasidone and Estradiol Interaction
Drug interaction information between Ziprasidone and Estradiol.
Ziprasidone and Estradiol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Ziprasidone and Estradiol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Ziprasidone does not change the way the body breaks down or removes estradiol from the system. This means the levels of the hormone in your blood stay the same.
FDA Label Information
Ziprasidone at a dose of 20 mg twice daily did not affect the pharmacokinetics of concomitantly administered oral contraceptives, ethinyl estradiol (0.03 mg) and levonorgestrel (0.15 mg).
Ziprasidone Also Interacts With
- Buspirone moderate
- Lithium moderate
- Tetrabenazine moderate
- Propranolol minor
- Lorazepam minor
Estradiol Also Interacts With
- Drospirenone/Ethinyl Estradiol major
- Glecaprevir/Pibrentasvir moderate
- Etonogestrel moderate
- Tacrolimus Topical moderate
- Rosuvastatin minor
Frequently Asked Questions
What SPL severity band is on file for Ziprasidone + Estradiol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Estradiol has 54 labeled pairs on file vs Ziprasidone's 18. In the minor band specifically: Ziprasidone has 15 (also Propranolol, Lorazepam, Progesterone, Ketoconazole); Estradiol has 50 (also Rosuvastatin, Lamotrigine, Topiramate, Tizanidine).
What mechanism field is on file for Ziprasidone and Estradiol?
Ziprasidone does not change the way the body breaks down or removes estradiol from the system. This means the levels of the hormone in your blood stay the same.
Estradiol carries more major-labeled pairs than Ziprasidone
SPL source-record counts only. This page's band is minor · classes on file: Ziprasidone (Atypical Antipsychotic); Estradiol (Estrogen Hormone).
Estradiol has 1 major-labeled pair vs Ziprasidone's 0. This page itself is in the minor band, not the major band.
0 major · 3 moderate · 15 minor · 18 total
- Other minor peers for Ziprasidone
- Propranolol
- Lorazepam
- Progesterone
- Ketoconazole
1 major · 3 moderate · 50 minor · 54 total
- Other minor peers for Estradiol
- Rosuvastatin
- Lamotrigine
- Topiramate
- Tizanidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.