Lorazepam and Clozapine Interaction
Drug interaction information between Lorazepam and Clozapine.
Lorazepam and Clozapine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Lorazepam and Clozapine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Combining these medications can cause a dangerous increase in side effects like extreme sleepiness and slowed breathing.
FDA Label Information
Concomitant use of clozapine and lorazepam may produce marked sedation, excessive salivation, hypotension, ataxia, delirium, and respiratory arrest.
Lorazepam Also Interacts With
- Valproate minor
- Probenecid minor
- Theophylline minor
- Aripiprazole minor
- Clarithromycin minor
Clozapine Also Interacts With
- Cyclobenzaprine moderate
- Diphenhydramine moderate
- Fluoxetine moderate
- Sertraline minor
- Escitalopram minor
Frequently Asked Questions
What SPL severity band is on file for Lorazepam + Clozapine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clozapine has 42 labeled pairs on file vs Lorazepam's 11. In the minor band specifically: Lorazepam has 11 (also Valproate, Probenecid, Theophylline, Aripiprazole); Clozapine has 39 (also Sertraline, Escitalopram, Bupropion, Duloxetine).
What mechanism field is on file for Lorazepam and Clozapine?
Combining these medications can cause a dangerous increase in side effects like extreme sleepiness and slowed breathing.
Clozapine's labeled portfolio outnumbers Lorazepam
SPL source-record counts only. This page's band is minor · classes on file: Lorazepam (Benzodiazepine); Clozapine (Atypical Antipsychotic).
0 major · 0 moderate · 11 minor · 11 total
- Other minor peers for Lorazepam
- Valproate
- Probenecid
- Theophylline
- Aripiprazole
0 major · 3 moderate · 39 minor · 42 total
- Other minor peers for Clozapine
- Sertraline
- Escitalopram
- Bupropion
- Duloxetine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.