What the FDA labels say about taking them together
Clozapine and lorazepam
Lorazepam's FDA label of July 9, 2025 names clozapine in its drug interactions section; the clozapine labels PlainMeds reads (2) do not name lorazepam. The lorazepam label: “Concomitant use of clozapine and lorazepam may produce marked sedation, excessive salivation, hypotension, ataxia, delirium, and respiratory arrest.”
Check it at the source: the clozapine FDA label on DailyMed (effective June 6, 2025, HLS Therapeutics (USA), Inc.); the lorazepam FDA label on DailyMed (effective July 9, 2025, Bausch Health US LLC).
What does the clozapine label say about lorazepam?
Clozapine's label (effective June 6, 2025) and its 1 other brand-application label do not name lorazepam in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Clozaril), NDA019758 (Heritage Life), as published by HLS Therapeutics (USA), Inc., effective June 6, 2025 (SPL set 90876802-0e3a-44c9-9ff7-1754dfbe736a), via openFDA; the full label on DailyMed
What does the lorazepam label say about clozapine?
Lorazepam label, drug interactionsConcomitant use of clozapine and lorazepam may produce marked sedation, excessive salivation, hypotension, ataxia, delirium, and respiratory arrest.
Loreev Xr label (Almatica Pharma LLC, October 8, 2025), drug interactionsCNS-Depressants Clinical Impact Benzodiazepines, including LOREEV XR, increase CNS-depressant effects when administered with other CNS depressants. Concomitant use of clozapine and LOREEV XR may produce marked sedation, excessive salivation, hypotension, ataxia, delirium, and respiratory arrest. Intervention Avoid co-administration of alcohol with LOREEV XR. Use caution if LOREEV XR is co-administered with other CNS-depressants [see Warnings and Precautions (5.4)].
Lorazepam label (Hikma Pharmaceuticals USA Inc., April 10, 2024), drug interactionsThe risk of using lorazepam in combination with scopolamine, loxapine, clozapine, haloperidol, or other CNS-depressant drugs has not been systematically evaluated.
Source: FDA drug label (Loreev Xr, NDA214826), Almatica Pharma LLC, effective October 8, 2025 (SPL set 227734c1-bf01-9607-73ea-5a1f38a89bd9), via openFDA
Source: FDA drug label (Lorazepam, NDA018140), Hikma Pharmaceuticals USA Inc., effective April 10, 2024 (SPL set 4084fa74-9fd2-45ef-9d56-27bfa31d4e46), via openFDA
Source: FDA drug label (Ativan), Bausch Health US LLC, effective July 9, 2025 (SPL set 89057c93-8155-4040-acec-64e877bd2b4c), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Clozapine | Lorazepam | |
|---|---|---|
| Labeled for | Schizophrenia | Anxiety |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.610 per tablet 100 mg tablet | $0.0344 per tablet 0.5 mg tablet |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once