Ziprasidone and Tetrabenazine Interaction
Drug interaction information between Ziprasidone and Tetrabenazine.
Ziprasidone and Tetrabenazine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Ziprasidone and Tetrabenazine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs can cause a dangerous change in the heart's rhythm and increase the risk of serious movement problems.
FDA Label Information
7.5 Drugs That Cause QTc Prolongation Tetrabenazine causes a small prolongation of QTc (about 8 msec), concomitant use with other drugs that are known to cause QTc prolongation should be avoided, these including antipsychotic medications (e.g., chlorpromazine, haloperidol, thioridazine, ziprasidone), antibiotics (e.g., moxifloxacin), Class 1A (e.g., quinidine, procainamide) and Class III (e.g., amiodarone, sotalol) antiarrhythmic medications or any other medications known to prolong the QTc interval. 7.6 Neuroleptic Drugs The risk for Parkinsonism, NMS, and akathisia may be increased by...
Ziprasidone Also Interacts With
- Buspirone moderate
- Lithium moderate
- Estradiol minor
- Propranolol minor
- Lorazepam minor
Tetrabenazine Also Interacts With
- Deutetrabenazine major
- Valbenazine major
- Olanzapine moderate
- Risperidone moderate
- Haloperidol moderate
Frequently Asked Questions
What SPL severity band is on file for Ziprasidone + Tetrabenazine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ziprasidone has 18 labeled pairs on file vs Tetrabenazine's 16. In the moderate band specifically: Ziprasidone has 3 (also Buspirone, Lithium); Tetrabenazine has 9 (also Olanzapine, Risperidone, Haloperidol, Chlorpromazine).
What mechanism field is on file for Ziprasidone and Tetrabenazine?
Both drugs can cause a dangerous change in the heart's rhythm and increase the risk of serious movement problems.
Tetrabenazine carries more major-labeled pairs than Ziprasidone
SPL source-record counts only. This page's band is moderate · classes on file: Ziprasidone (Atypical Antipsychotic); Tetrabenazine (VMAT2 Inhibitor).
Tetrabenazine has 2 major-labeled pairs vs Ziprasidone's 0. This page itself is in the moderate band, not the major band.
0 major · 3 moderate · 15 minor · 18 total
2 major · 9 moderate · 5 minor · 16 total
- Other moderate peers for Tetrabenazine
- Olanzapine
- Risperidone
- Haloperidol
- Chlorpromazine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.