What the FDA labels say about taking them together
Lorazepam and probenecid
Lorazepam's FDA label of July 9, 2025 names probenecid in its drug interactions section, and probenecid's label names lorazepam too. The lorazepam label: “Concurrent administration of lorazepam with probenecid may result in a more rapid onset or prolonged effect of lorazepam due to increased half-life and decreased total clearance.”
Check it at the source: the lorazepam FDA label on DailyMed (effective July 9, 2025, Bausch Health US LLC); the probenecid FDA label on DailyMed (effective January 5, 2021, Lannett Company, Inc.).
What does the lorazepam label say about probenecid?
Lorazepam label, drug interactionsConcurrent administration of lorazepam with probenecid may result in a more rapid onset or prolonged effect of lorazepam due to increased half-life and decreased total clearance.
Lorazepam label (Hikma Pharmaceuticals USA Inc., April 10, 2024), drug interactionsLORAZEPAM-PROBENECID INTERACTION Concurrent administration of lorazepam (2 mg intravenously) with probenecid (500 mg orally every 6 hours) to 9 healthy volunteers resulted in a prolongation of lorazepam half-life by 130% and a decrease in its total clearance by 45%.
Source: FDA drug label (Lorazepam, NDA018140), Hikma Pharmaceuticals USA Inc., effective April 10, 2024 (SPL set 4084fa74-9fd2-45ef-9d56-27bfa31d4e46), via openFDA
Source: FDA drug label (Ativan), Bausch Health US LLC, effective July 9, 2025 (SPL set 89057c93-8155-4040-acec-64e877bd2b4c), via openFDA; the full label on DailyMed
What does the probenecid label say about lorazepam?
Probenecid label, drug interactionsThese include agents such as indomethacin, acetaminophen, naproxen, ketoprofen, meclofenamate, lorazepam, and rifampin.
Source: FDA drug label (Probenecid), Lannett Company, Inc., effective January 5, 2021 (SPL set ab497fd8-00c3-4364-b003-b39d21fbdf38), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Lorazepam | Probenecid | |
|---|---|---|
| Labeled for | Anxiety | Gout |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0344 per tablet 0.5 mg tablet | $0.636 per tablet 500 mg tablet |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once