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What the FDA labels say about taking them together

Lorazepam and theophylline

Lorazepam's FDA label of July 9, 2025 names theophylline in its drug interactions section, and theophylline's label names lorazepam too. The lorazepam label: “Administration of theophylline or aminophylline may reduce the sedative effects of benzodiazepines, including lorazepam.”

Check it at the source: the lorazepam FDA label on DailyMed (effective July 9, 2025, Bausch Health US LLC); the theophylline FDA label on DailyMed (effective March 10, 2026, Strides Pharma Science Limited).

What does the lorazepam label say about theophylline?

Lorazepam label, drug interactions

Administration of theophylline or aminophylline may reduce the sedative effects of benzodiazepines, including lorazepam.

Source: FDA drug label (Ativan), Bausch Health US LLC, effective July 9, 2025 (SPL set 89057c93-8155-4040-acec-64e877bd2b4c), via openFDA; the full label on DailyMed

What does the theophylline label say about lorazepam?

Theophylline label, drug interactions

Lorazepam Similar to diazepam.

Source: FDA drug label (Theophylline), Strides Pharma Science Limited, effective March 10, 2026 (SPL set b7a90ccf-9c32-40cc-9008-7e55b3da4dfd), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

36Lorazepam generic labelers
26Theophylline generic labelers
LorazepamTheophylline
Labeled forAnxietyAsthma
Boxed warningYesNo
Pharmacy cost (NADAC)$0.0344 per tablet 0.5 mg tablet$0.330 per tablet 300 mg tablet
Shortage nowIn shortageNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

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