Lorazepam and Theophylline Interaction
Drug interaction information between Lorazepam and Theophylline.
Lorazepam and Theophylline have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Lorazepam and Theophylline. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Theophylline acts as a stimulant that can cancel out the calming or sleepy effects of lorazepam.
FDA Label Information
Administration of theophylline or aminophylline may reduce the sedative effects of benzodiazepines, including lorazepam.
Lorazepam Also Interacts With
- Valproate minor
- Clozapine minor
- Probenecid minor
- Aripiprazole minor
- Clarithromycin minor
Theophylline Also Interacts With
- Metoprolol major
- Albuterol major
- Omeprazole major
- Amoxicillin major
- Famotidine major
Frequently Asked Questions
What SPL severity band is on file for Lorazepam + Theophylline?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Theophylline has 86 labeled pairs on file vs Lorazepam's 11. In the minor band specifically: Lorazepam has 11 (also Valproate, Clozapine, Probenecid, Aripiprazole); Theophylline has 54 (also Propranolol, Methotrexate, Diazepam, Lithium).
What mechanism field is on file for Lorazepam and Theophylline?
Theophylline acts as a stimulant that can cancel out the calming or sleepy effects of lorazepam.
Theophylline carries more major-labeled pairs than Lorazepam
SPL source-record counts only. This page's band is minor · classes on file: Lorazepam (Benzodiazepine); Theophylline (Methylxanthine Bronchodilator).
Theophylline has 27 major-labeled pairs vs Lorazepam's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 11 minor · 11 total
- Other minor peers for Lorazepam
- Valproate
- Clozapine
- Probenecid
- Aripiprazole
27 major · 5 moderate · 54 minor · 86 total
- Other minor peers for Theophylline
- Propranolol
- Methotrexate
- Diazepam
- Lithium
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.