Lorazepam and Aripiprazole Interaction
Drug interaction information between Lorazepam and Aripiprazole.
Lorazepam and Aripiprazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Lorazepam and Aripiprazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs can cause sleepiness and low blood pressure, and taking them together makes these side effects much stronger.
FDA Label Information
Benzodiazepines (e.g., lorazepam) The intensity of sedation was greater with the combination of oral aripiprazole and lorazepam as compared to that observed with aripiprazole alone. The orthostatic hypotension observed was greater with the combination as compared to that observed with lorazepam alone [see Warnings and Precautions (5.8)] Monitor sedation and blood pressure. 7.2 Drugs Having No Clinically Important Interactions with Aripiprazole Based on pharmacokinetic studies, no dosage adjustment of aripiprazole is required when administered concomitantly with famotidine, valproate,...
Lorazepam Also Interacts With
- Valproate minor
- Clozapine minor
- Probenecid minor
- Theophylline minor
- Clarithromycin minor
Aripiprazole Also Interacts With
- Omeprazole minor
- Sertraline minor
- Escitalopram minor
- Fluoxetine minor
- Famotidine minor
Frequently Asked Questions
What SPL severity band is on file for Lorazepam + Aripiprazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Aripiprazole has 19 labeled pairs on file vs Lorazepam's 11. In the minor band specifically: Lorazepam has 11 (also Valproate, Clozapine, Probenecid, Theophylline); Aripiprazole has 19 (also Omeprazole, Sertraline, Escitalopram, Fluoxetine).
What mechanism field is on file for Lorazepam and Aripiprazole?
Both drugs can cause sleepiness and low blood pressure, and taking them together makes these side effects much stronger.
Aripiprazole's labeled portfolio outnumbers Lorazepam
SPL source-record counts only. This page's band is minor · classes on file: Lorazepam (Benzodiazepine); Aripiprazole (Atypical Antipsychotic).
0 major · 0 moderate · 11 minor · 11 total
- Other minor peers for Lorazepam
- Valproate
- Clozapine
- Probenecid
- Theophylline
0 major · 0 moderate · 19 minor · 19 total
- Other minor peers for Aripiprazole
- Omeprazole
- Sertraline
- Escitalopram
- Fluoxetine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.