Lorazepam and Aripiprazole Interaction
Drug interaction information between Lorazepam and Aripiprazole.
Lorazepam and Aripiprazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Lorazepam and Aripiprazole. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Both drugs can cause sleepiness and low blood pressure, and taking them together makes these side effects much stronger.
What To Do
Your healthcare provider should monitor you closely for extreme sleepiness and changes in your blood pressure.
FDA Label Information
Benzodiazepines (e.g., lorazepam) The intensity of sedation was greater with the combination of oral aripiprazole and lorazepam as compared to that observed with aripiprazole alone. The orthostatic hypotension observed was greater with the combination as compared to that observed with lorazepam alone [see Warnings and Precautions (5.8)] Monitor sedation and blood pressure. 7.2 Drugs Having No Clinically Important Interactions with Aripiprazole Based on pharmacokinetic studies, no dosage adjustment of aripiprazole is required when administered concomitantly with famotidine, valproate,...
Lorazepam Also Interacts With
- Valproate minor
- Clozapine minor
- Probenecid minor
- Theophylline minor
- Clarithromycin minor
Aripiprazole Also Interacts With
- Omeprazole minor
- Sertraline minor
- Escitalopram minor
- Fluoxetine minor
- Famotidine minor
Frequently Asked Questions
Can I take Lorazepam and Aripiprazole together?
This is a minor interaction. Your healthcare provider should monitor you closely for extreme sleepiness and changes in your blood pressure.
How serious is the interaction between Lorazepam and Aripiprazole?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Lorazepam and Aripiprazole interact?
Both drugs can cause sleepiness and low blood pressure, and taking them together makes these side effects much stronger.
Understanding the Lorazepam and Aripiprazole Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Lorazepam belongs to the Benzodiazepine class and Aripiprazole belongs to the Atypical Antipsychotic class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Both drugs can cause sleepiness and low blood pressure, and taking them together makes these side effects much stronger. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Lorazepam has 11 total documented interactions on file in this dataset, and Aripiprazole has 19. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your healthcare provider should monitor you closely for extreme sleepiness and changes in your blood pressure. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Lorazepam or Aripiprazole based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.