Valbenazine and Itraconazole Interaction
Drug interaction information between Valbenazine and Itraconazole.
Valbenazine and Itraconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Valbenazine and Itraconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Itraconazole prevents your body from processing valbenazine normally. This causes the drug to reach higher levels in your blood.
FDA Label Information
Valbenazine Concomitant drug dose reduction is necessary. Refer to the valbenazine prescribing information for dosing instructions.
Valbenazine Also Interacts With
- Deutetrabenazine major
- Tetrabenazine major
- Digoxin moderate
Itraconazole Also Interacts With
- Isavuconazonium major
- Lurasidone major
- Pimozide major
- Methadone major
- Midazolam major
Frequently Asked Questions
What SPL severity band is on file for Valbenazine + Itraconazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Itraconazole has 116 labeled pairs on file vs Valbenazine's 4. In the minor band specifically: Valbenazine has 1; Itraconazole has 77 (also Fluticasone, Meloxicam, Buspirone, Oxycodone).
What mechanism field is on file for Valbenazine and Itraconazole?
Itraconazole prevents your body from processing valbenazine normally. This causes the drug to reach higher levels in your blood.
Itraconazole carries more major-labeled pairs than Valbenazine
SPL source-record counts only. This page's band is minor · classes on file: Valbenazine (VMAT2 Inhibitor); Itraconazole (Azole Antifungal).
Itraconazole has 19 major-labeled pairs vs Valbenazine's 2. This page itself is in the minor band, not the major band.
2 major · 1 moderate · 1 minor · 4 total
Valbenazine has no other minor-band peer in this dataset besides Itraconazole.
19 major · 20 moderate · 77 minor · 116 total
- Other minor peers for Itraconazole
- Fluticasone
- Meloxicam
- Buspirone
- Oxycodone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.