Valbenazine and Digoxin Interaction
Drug interaction information between Valbenazine and Digoxin.
Valbenazine and Digoxin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Valbenazine and Digoxin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Valbenazine blocks a protein in the gut that normally pumps digoxin out of the body, which causes digoxin levels in the blood to rise.
FDA Label Information
Digoxin Clinical Implication: Concomitant use of INGREZZA or INGREZZA SPRINKLE with digoxin increased digoxin levels because of inhibition of intestinal P-glycoprotein (P-gp) [see Clinical Pharmacology ( 12.3 )] . Prevention or Management: Digoxin concentrations should be monitored when co-administering INGREZZA or INGREZZA SPRINKLE with digoxin. Increased digoxin exposure may increase the risk of exposure-related adverse reactions.
Valbenazine Also Interacts With
- Deutetrabenazine major
- Tetrabenazine major
- Itraconazole minor
Digoxin Also Interacts With
- Nicardipine major
- Posaconazole major
- Sotalol moderate
- Dofetilide moderate
- Ivabradine moderate
Frequently Asked Questions
What SPL severity band is on file for Valbenazine + Digoxin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Digoxin has 120 labeled pairs on file vs Valbenazine's 4. In the moderate band specifically: Valbenazine has 1; Digoxin has 13 (also Sotalol, Dofetilide, Ivabradine, Dopamine).
What mechanism field is on file for Valbenazine and Digoxin?
Valbenazine blocks a protein in the gut that normally pumps digoxin out of the body, which causes digoxin levels in the blood to rise.
Digoxin's labeled portfolio outnumbers Valbenazine
SPL source-record counts only. This page's band is moderate · classes on file: Valbenazine (VMAT2 Inhibitor); Digoxin (Cardiac Glycoside).
2 major · 1 moderate · 1 minor · 4 total
Valbenazine has no other moderate-band peer in this dataset besides Digoxin.
2 major · 13 moderate · 105 minor · 120 total
- Other moderate peers for Digoxin
- Sotalol
- Dofetilide
- Ivabradine
- Dopamine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.