Valbenazine and Deutetrabenazine Interaction
Drug interaction information between Valbenazine and Deutetrabenazine.
Valbenazine and Deutetrabenazine have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Valbenazine and Deutetrabenazine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These two medicines work in the same way, and taking them at the same time can cause the drug effects to become too strong and unsafe.
FDA Label Information
7.6 Concomitant Tetrabenazine or Valbenazine AUSTEDO XR and AUSTEDO are contraindicated in patients currently taking tetrabenazine or valbenazine.
Valbenazine Also Interacts With
- Tetrabenazine major
- Digoxin moderate
- Itraconazole minor
Deutetrabenazine Also Interacts With
- Tetrabenazine major
- Dopamine moderate
- Norepinephrine moderate
- Bupropion minor
- Fluoxetine minor
Frequently Asked Questions
What SPL severity band is on file for Valbenazine + Deutetrabenazine?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Deutetrabenazine has 7 labeled pairs on file vs Valbenazine's 4. In the major band specifically: Valbenazine has 2 (also Tetrabenazine); Deutetrabenazine has 2 (also Tetrabenazine).
What mechanism field is on file for Valbenazine and Deutetrabenazine?
These two medicines work in the same way, and taking them at the same time can cause the drug effects to become too strong and unsafe.
Deutetrabenazine's labeled portfolio outnumbers Valbenazine
SPL source-record counts only. This page's band is major · classes on file: Valbenazine (VMAT2 Inhibitor); Deutetrabenazine (VMAT2 Inhibitor).
2 major · 1 moderate · 1 minor · 4 total
- Other major peers for Valbenazine
- Tetrabenazine
2 major · 2 moderate · 3 minor · 7 total
- Other major peers for Deutetrabenazine
- Tetrabenazine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.