Valbenazine and Deutetrabenazine Interaction
Drug interaction information between Valbenazine and Deutetrabenazine.
Valbenazine and Deutetrabenazine have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Valbenazine and Deutetrabenazine. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
These two medicines work in the same way, and taking them at the same time can cause the drug effects to become too strong and unsafe.
What To Do
Do not take these two medications together; your doctor will have you stop one before starting the other.
FDA Label Information
7.6 Concomitant Tetrabenazine or Valbenazine AUSTEDO XR and AUSTEDO are contraindicated in patients currently taking tetrabenazine or valbenazine.
Valbenazine Also Interacts With
- Tetrabenazine major
- Digoxin moderate
- Itraconazole minor
Deutetrabenazine Also Interacts With
- Tetrabenazine major
- Dopamine moderate
- Norepinephrine moderate
- Bupropion minor
- Fluoxetine minor
Frequently Asked Questions
Can I take Valbenazine and Deutetrabenazine together?
This is a major interaction. Do not take these two medications together; your doctor will have you stop one before starting the other.
How serious is the interaction between Valbenazine and Deutetrabenazine?
This interaction is classified as "major" severity by the FDA. Major interactions may be life-threatening or cause serious side effects.
Why do Valbenazine and Deutetrabenazine interact?
These two medicines work in the same way, and taking them at the same time can cause the drug effects to become too strong and unsafe.
Understanding the Valbenazine and Deutetrabenazine Interaction
FDA-approved prescribing information for these two drugs flags their combination as a major-severity interaction. Valbenazine belongs to the VMAT2 Inhibitor class and Deutetrabenazine belongs to the VMAT2 Inhibitor class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: These two medicines work in the same way, and taking them at the same time can cause the drug effects to become too strong and unsafe. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Valbenazine has 4 total documented interactions on file in this dataset, and Deutetrabenazine has 7. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Do not take these two medications together; your doctor will have you stop one before starting the other. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Valbenazine or Deutetrabenazine based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.