Valbenazine and Tetrabenazine Interaction
Drug interaction information between Valbenazine and Tetrabenazine.
Valbenazine and Tetrabenazine have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Valbenazine and Tetrabenazine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These medications are designed to do the same thing in the brain to control body movements. Using both at once increases the risk of dangerous side effects because they have the same target.
FDA Label Information
7.7 Concomitant Deutetrabenazine or Valbenazine Tetrabenazine is contraindicated in patients currently taking deutetrabenazine or valbenazine.
Valbenazine Also Interacts With
- Deutetrabenazine major
- Digoxin moderate
- Itraconazole minor
Tetrabenazine Also Interacts With
- Deutetrabenazine major
- Olanzapine moderate
- Risperidone moderate
- Ziprasidone moderate
- Haloperidol moderate
Frequently Asked Questions
What SPL severity band is on file for Valbenazine + Tetrabenazine?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Tetrabenazine has 16 labeled pairs on file vs Valbenazine's 4. In the major band specifically: Valbenazine has 2 (also Deutetrabenazine); Tetrabenazine has 2 (also Deutetrabenazine).
What mechanism field is on file for Valbenazine and Tetrabenazine?
These medications are designed to do the same thing in the brain to control body movements. Using both at once increases the risk of dangerous side effects because they have the same target.
Tetrabenazine's labeled portfolio outnumbers Valbenazine
SPL source-record counts only. This page's band is major · classes on file: Valbenazine (VMAT2 Inhibitor); Tetrabenazine (VMAT2 Inhibitor).
2 major · 1 moderate · 1 minor · 4 total
- Other major peers for Valbenazine
- Deutetrabenazine
2 major · 9 moderate · 5 minor · 16 total
- Other major peers for Tetrabenazine
- Deutetrabenazine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.