Timolol and Verapamil Interaction
Drug interaction information between Timolol and Verapamil.
Timolol and Verapamil have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Timolol and Verapamil. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Even as eye drops, timolol can combine with verapamil to significantly slow down your heart rate.
FDA Label Information
Asymptomatic bradycardia (36 beats/min) with a wandering atrial pacemaker has been observed in a patient receiving concomitant timolol (a beta-adrenergic blocker) eyedrops and oral verapamil.
Timolol Also Interacts With
- Dorzolamide moderate
- Clonidine minor
- Brimonidine/Timolol minor
- Darunavir minor
- Dorzolamide/Timolol minor
Verapamil Also Interacts With
- Eplerenone major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Simvastatin major
- Clarithromycin moderate
Frequently Asked Questions
What SPL severity band is on file for Timolol + Verapamil?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Verapamil has 57 labeled pairs on file vs Timolol's 6. In the minor band specifically: Timolol has 5 (also Clonidine, Brimonidine/Timolol, Darunavir, Dorzolamide/Timolol); Verapamil has 47 (also Atorvastatin, Aspirin, Atenolol, Cyclosporine).
What mechanism field is on file for Timolol and Verapamil?
Even as eye drops, timolol can combine with verapamil to significantly slow down your heart rate.
Verapamil carries more major-labeled pairs than Timolol
SPL source-record counts only. This page's band is minor · classes on file: Timolol (Beta-Blocker (Ophthalmic)); Verapamil (Calcium Channel Blocker).
Verapamil has 4 major-labeled pairs vs Timolol's 0. This page itself is in the minor band, not the major band.
0 major · 1 moderate · 5 minor · 6 total
- Other minor peers for Timolol
- Clonidine
- Brimonidine/Timolol
- Darunavir
- Dorzolamide/Timolol
4 major · 6 moderate · 47 minor · 57 total
- Other minor peers for Verapamil
- Atorvastatin
- Aspirin
- Atenolol
- Cyclosporine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.