Timolol and Brimonidine/Timolol Interaction
Drug interaction information between Timolol and Brimonidine/Timolol.
Timolol and Brimonidine/Timolol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Timolol and Brimonidine/Timolol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Certain medicines can block the body from breaking down timolol. This can lead to higher levels of the drug in your system, which may cause a slow heart rate or feelings of depression.
FDA Label Information
7.7 CYP2D6 Inhibitors Potentiated systemic beta-blockade (e.g., decreased heart rate, depression) has been reported during combined treatment with CYP2D6 inhibitors (e.g., quinidine, SSRIs) and timolol.
Timolol Also Interacts With
- Dorzolamide moderate
- Clonidine minor
- Darunavir minor
- Dorzolamide/Timolol minor
- Verapamil minor
Frequently Asked Questions
What SPL severity band is on file for Timolol + Brimonidine/Timolol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Timolol has 6 labeled pairs on file vs Brimonidine/Timolol's 2. In the minor band specifically: Timolol has 5 (also Clonidine, Darunavir, Dorzolamide/Timolol, Verapamil); Brimonidine/Timolol has 2 (also Clonidine).
What mechanism field is on file for Timolol and Brimonidine/Timolol?
Certain medicines can block the body from breaking down timolol. This can lead to higher levels of the drug in your system, which may cause a slow heart rate or feelings of depression.
Timolol's labeled portfolio outnumbers Brimonidine/Timolol
SPL source-record counts only. This page's band is minor · classes on file: Timolol (Beta-Blocker (Ophthalmic)); Brimonidine/Timolol (Alpha-2 Agonist / Beta-Blocker Combination).
0 major · 1 moderate · 5 minor · 6 total
- Other minor peers for Timolol
- Clonidine
- Darunavir
- Dorzolamide/Timolol
- Verapamil
0 major · 0 moderate · 2 minor · 2 total
- Other minor peers for Brimonidine/Timolol
- Clonidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.