timolol vs verapamil

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Side-by-side comparison of timolol and verapamil. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.

minor Known Drug Interaction

Asymptomatic bradycardia (36 beats/min) with a wandering atrial pacemaker has been observed in a patient receiving concomitant timolol (a beta-adrenergic blocker) eyedrops and oral verapamil.

Drug Class
timolol Beta-Blocker (Ophthalmic)
verapamil Calcium Channel Blocker
Type
timolol Prescription
verapamil Prescription
Summary
timolol

No summary available.

verapamil

Verapamil is a drug that helps to lower blood pressure and treat chest pain (angina) and irregular heartbeats (arrhythmias). It works by relaxing blood vessels and slowing down the heart rate.

What It Treats
timolol

Information not available.

verapamil

Verapamil is used to treat chest pain called angina. This includes angina that happens when you are resting or during normal activity. It is also used to control your heart rate if you have a fast or irregular heartbeat, such as atrial fibrillation or atrial flutter. Verapamil also treats high blood pressure.

How It Works
timolol

Information not available.

verapamil

Verapamil belongs to a class of drugs called calcium channel blockers. It works by blocking calcium from entering heart and blood vessel cells. This relaxes and widens blood vessels, which lowers blood pressure and makes it easier for the heart to pump.

Common Side Effects
timolol
  • Bitter, sour, or unusual taste
  • Eye burning or stinging
  • Redness of the eye
  • Blurred vision
  • Eye itching
verapamil
  • Constipation
  • Shortness of breath
  • Dizziness
  • Slow heart rate (less than 50 beats per minute)
  • Nausea
FAERS Reports
timolol
  • Treatment Failure 3,042
  • Fatigue 470
  • Hypersensitivity 456
  • Dizziness 401
  • Diarrhoea 396
verapamil
  • Dyspnoea 356
  • Nausea 341
  • Drug Interaction 316
  • Dizziness 286
  • Hypotension 280
Serious Warnings
timolol

No specific warnings noted.

verapamil

You should not take this medicine if you have severe heart problems, very low blood pressure, or certain types of irregular heartbeats without a pacemaker. Talk to your doctor if you have any of these conditions.

Pregnancy
timolol

No pregnancy information available.

verapamil

Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. It is not known if verapamil will harm your unborn baby. Verapamil can pass into breast milk, so talk to your doctor about the best way to feed your baby if you take this medicine.

Also Compare, Nearby Drugs

How to Read This timolol vs verapamil Comparison

timolol is classified in the Beta-Blocker (Ophthalmic) drug class, while verapamil sits within the Calcium Channel Blocker class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.

Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, timolol has 4,765 submissions while verapamil has 1,579. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to even as eye drops, timolol can combine with verapamil to significantly slow down your heart rate.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.

A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for timolol or verapamil.

Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.