Verapamil and Cyclosporine Interaction
Drug interaction information between Verapamil and Cyclosporine.
Verapamil and Cyclosporine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Verapamil and Cyclosporine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Verapamil can cause the amount of cyclosporine in your blood to rise to higher levels than normal.
FDA Label Information
Cyclosporine: Verapamil therapy may increase serum levels of cyclosporine.
Verapamil Also Interacts With
- Eplerenone major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Simvastatin major
- Clarithromycin moderate
Cyclosporine Also Interacts With
- Clarithromycin major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Pitavastatin major
- Simvastatin major
Frequently Asked Questions
What SPL severity band is on file for Verapamil + Cyclosporine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cyclosporine has 89 labeled pairs on file vs Verapamil's 57. In the minor band specifically: Verapamil has 47 (also Atorvastatin, Aspirin, Atenolol, Timolol); Cyclosporine has 60 (also Adalimumab, Amiodarone, Amlodipine, Anidulafungin).
What mechanism field is on file for Verapamil and Cyclosporine?
Verapamil can cause the amount of cyclosporine in your blood to rise to higher levels than normal.
Cyclosporine carries more major-labeled pairs than Verapamil
SPL source-record counts only. This page's band is minor · classes on file: Verapamil (Calcium Channel Blocker); Cyclosporine (Calcineurin Inhibitor (Immunosuppressant)).
Cyclosporine has 5 major-labeled pairs vs Verapamil's 4. This page itself is in the minor band, not the major band.
4 major · 6 moderate · 47 minor · 57 total
- Other minor peers for Verapamil
- Atorvastatin
- Aspirin
- Atenolol
- Timolol
5 major · 24 moderate · 60 minor · 89 total
- Other minor peers for Cyclosporine
- Adalimumab
- Amiodarone
- Amlodipine
- Anidulafungin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.