Timolol and Darunavir Interaction
Drug interaction information between Timolol and Darunavir.
Timolol and Darunavir have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Timolol and Darunavir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Darunavir prevents the body from clearing timolol quickly, which can cause the beta-blocker to build up to higher levels.
FDA Label Information
carvedilol, metoprolol, timolol ↑ beta-blockers Clinical monitoring of patients is recommended.
Timolol Also Interacts With
- Dorzolamide moderate
- Clonidine minor
- Brimonidine/Timolol minor
- Dorzolamide/Timolol minor
- Verapamil minor
Darunavir Also Interacts With
- Lovastatin major
- Sildenafil major
- Lurasidone major
- Pimozide major
- Midazolam major
Frequently Asked Questions
What SPL severity band is on file for Timolol + Darunavir?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Darunavir has 101 labeled pairs on file vs Timolol's 6. In the minor band specifically: Timolol has 5 (also Clonidine, Brimonidine/Timolol, Dorzolamide/Timolol, Verapamil); Darunavir has 70 (also Amlodipine, Metoprolol, Sertraline, Rosuvastatin).
What mechanism field is on file for Timolol and Darunavir?
Darunavir prevents the body from clearing timolol quickly, which can cause the beta-blocker to build up to higher levels.
Darunavir carries more major-labeled pairs than Timolol
SPL source-record counts only. This page's band is minor · classes on file: Timolol (Beta-Blocker (Ophthalmic)); Darunavir (HIV Protease Inhibitor).
Darunavir has 15 major-labeled pairs vs Timolol's 0. This page itself is in the minor band, not the major band.
0 major · 1 moderate · 5 minor · 6 total
- Other minor peers for Timolol
- Clonidine
- Brimonidine/Timolol
- Dorzolamide/Timolol
- Verapamil
15 major · 16 moderate · 70 minor · 101 total
- Other minor peers for Darunavir
- Amlodipine
- Metoprolol
- Sertraline
- Rosuvastatin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.