Timolol and Clonidine Interaction
Drug interaction information between Timolol and Clonidine.
Timolol and Clonidine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Timolol and Clonidine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Timolol is a beta-blocker that can make blood pressure rise even higher if you suddenly stop taking clonidine. This happens because the two drugs affect the nervous system's control of blood pressure in opposite ways.
FDA Label Information
7.8 Clonidine Oral beta-adrenergic blocking agents may exacerbate the rebound hypertension which can follow the withdrawal of clonidine.
Timolol Also Interacts With
- Dorzolamide moderate
- Brimonidine/Timolol minor
- Darunavir minor
- Dorzolamide/Timolol minor
- Verapamil minor
Clonidine Also Interacts With
- Carvedilol moderate
- Metoprolol moderate
- Repaglinide moderate
- Sotalol moderate
- Amitriptyline minor
Frequently Asked Questions
What SPL severity band is on file for Timolol + Clonidine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clonidine has 29 labeled pairs on file vs Timolol's 6. In the minor band specifically: Timolol has 5 (also Brimonidine/Timolol, Darunavir, Dorzolamide/Timolol, Verapamil); Clonidine has 25 (also Amitriptyline, Diltiazem, Verapamil, Haloperidol).
What mechanism field is on file for Timolol and Clonidine?
Timolol is a beta-blocker that can make blood pressure rise even higher if you suddenly stop taking clonidine. This happens because the two drugs affect the nervous system's control of blood pressure in opposite ways.
Clonidine's labeled portfolio outnumbers Timolol
SPL source-record counts only. This page's band is minor · classes on file: Timolol (Beta-Blocker (Ophthalmic)); Clonidine (Central Alpha-2 Agonist).
0 major · 1 moderate · 5 minor · 6 total
- Other minor peers for Timolol
- Brimonidine/Timolol
- Darunavir
- Dorzolamide/Timolol
- Verapamil
0 major · 4 moderate · 25 minor · 29 total
- Other minor peers for Clonidine
- Amitriptyline
- Diltiazem
- Verapamil
- Haloperidol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.