What the FDA labels say about taking them together
Clonidine and timolol
Timolol's FDA label (Timolol Maleate) of November 4, 2024 names clonidine in its drug interactions section; clonidine's label does not name timolol itself but warns about its class (Beta blockers).
Check it at the source: the clonidine FDA label on DailyMed (effective March 30, 2026, Unichem Pharmaceuticals (USA), Inc.); the timolol FDA label on DailyMed (effective June 27, 2025, Thea Pharma Inc.).
What does the clonidine label say about timolol?
Clonidine's label does not name timolol itself; it warns about its class (Beta blockers):
Clonidine label, drug interactionsMonitor heart rate in patients receiving clonidine concomitantly with agents known to affect sinus node function or AV nodal conduction, e.g. , digitalis, calcium channel blockers and beta-blockers.
Clonidine label, warningsThe likelihood of such reactions to discontinuation of clonidine therapy appears to be greater after administration of higher doses or continuation of concomitant beta-blocker treatment and special caution is therefore advised in these situations.
Source: FDA drug label (clonidine hydrochloride), Unichem Pharmaceuticals (USA), Inc., effective March 30, 2026 (SPL set 21bfa28f-20df-43fd-bb80-b720d3b40696), via openFDA; the full label on DailyMed
What does the timolol label say about clonidine?
Timolol Maleate label (Bausch & Lomb Americas Inc., November 4, 2024), drug interactionsOral beta-adrenergic blocking agents may exacerbate the rebound hypertension which can follow the withdrawal of clonidine.
Source: FDA drug label (Timolol Maleate, NDA021516), Bausch & Lomb Americas Inc., effective November 4, 2024 (SPL set b686bbad-1ef7-4b94-a316-4d182a40b89a), via openFDA
Source: FDA drug label (Timolol Maleate, NDA020330), Bausch & Lomb Americas Inc., effective March 26, 2025 (SPL set 581f80f7-4419-49e2-867d-40443c75409f), via openFDA
Source: FDA drug label (BETIMOL), Thea Pharma Inc., effective June 27, 2025 (SPL set 3ae775f4-340c-4bf4-aa49-8a31daba0f8b), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Clonidine | Timolol | |
|---|---|---|
| Labeled for | High blood pressure, ADHD, Pain | Glaucoma, High blood pressure, Migraine |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0241 per tablet 0.1 mg tablet | $0.774 per mL 0.5% eye drops |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once