Tadalafil and Tamsulosin Interaction
Drug interaction information between Tadalafil and Tamsulosin.
Tadalafil and Tamsulosin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Tadalafil and Tamsulosin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both medications can relax blood vessels, which may cause blood pressure to drop more than usual when they are used together.
FDA Label Information
Clinical pharmacology studies have been conducted with coadministration of tadalafil with doxazosin, tamsulosin or alfuzosin.
Tadalafil Also Interacts With
- Hydralazine/Isosorbide Dinitrate major
- Clarithromycin moderate
- Nirmatrelvir/Ritonavir moderate
- Amlodipine minor
- Metoprolol minor
Tamsulosin Also Interacts With
- Furosemide major
- Paroxetine moderate
- Warfarin moderate
- Erythromycin moderate
- Terbinafine moderate
Frequently Asked Questions
What SPL severity band is on file for Tadalafil + Tamsulosin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Tadalafil has 25 labeled pairs on file vs Tamsulosin's 18. In the minor band specifically: Tadalafil has 22 (also Amlodipine, Metoprolol, Aspirin, Warfarin); Tamsulosin has 9 (also Atenolol, Nifedipine, Ketoconazole, Enalapril).
What mechanism field is on file for Tadalafil and Tamsulosin?
Both medications can relax blood vessels, which may cause blood pressure to drop more than usual when they are used together.
Tadalafil's labeled portfolio outnumbers Tamsulosin
SPL source-record counts only. This page's band is minor · classes on file: Tadalafil (PDE5 Inhibitor); Tamsulosin (Alpha-1 Adrenergic Blocker).
1 major · 2 moderate · 22 minor · 25 total
- Other minor peers for Tadalafil
- Amlodipine
- Metoprolol
- Aspirin
- Warfarin
1 major · 8 moderate · 9 minor · 18 total
- Other minor peers for Tamsulosin
- Atenolol
- Nifedipine
- Ketoconazole
- Enalapril
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.