Tadalafil and Amlodipine Interaction
Drug interaction information between Tadalafil and Amlodipine.
Tadalafil and Amlodipine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Tadalafil and Amlodipine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs lower blood pressure, so taking them together can cause an additive effect that drops blood pressure further.
FDA Label Information
Clinical pharmacology studies were conducted to assess the effect of tadalafil on the potentiation of the blood-pressure-lowering effects of selected antihypertensive medications (amlodipine, angiotensin II receptor blockers, bendrofluazide, enalapril, and metoprolol).
Tadalafil Also Interacts With
- Hydralazine/Isosorbide Dinitrate major
- Clarithromycin moderate
- Nirmatrelvir/Ritonavir moderate
- Metoprolol minor
- Tamsulosin minor
Amlodipine Also Interacts With
- Simvastatin major
- Amlodipine/Benazepril major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Nirmatrelvir/Ritonavir moderate
Frequently Asked Questions
What SPL severity band is on file for Tadalafil + Amlodipine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Tadalafil has 25 labeled pairs on file vs Amlodipine's 15. In the minor band specifically: Tadalafil has 22 (also Metoprolol, Tamsulosin, Aspirin, Warfarin); Amlodipine has 10 (also Sildenafil, Cyclosporine, Amlodipine/Valsartan, Clarithromycin).
What mechanism field is on file for Tadalafil and Amlodipine?
Both drugs lower blood pressure, so taking them together can cause an additive effect that drops blood pressure further.
Amlodipine carries more major-labeled pairs than Tadalafil
SPL source-record counts only. This page's band is minor · classes on file: Tadalafil (PDE5 Inhibitor); Amlodipine (Calcium Channel Blocker).
Amlodipine has 4 major-labeled pairs vs Tadalafil's 1. This page itself is in the minor band, not the major band.
1 major · 2 moderate · 22 minor · 25 total
- Other minor peers for Tadalafil
- Metoprolol
- Tamsulosin
- Aspirin
- Warfarin
4 major · 1 moderate · 10 minor · 15 total
- Other minor peers for Amlodipine
- Sildenafil
- Cyclosporine
- Amlodipine/Valsartan
- Clarithromycin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.