Tamsulosin and Erythromycin Interaction
Drug interaction information between Tamsulosin and Erythromycin.
Tamsulosin and Erythromycin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Tamsulosin and Erythromycin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Erythromycin may slow down the way your body gets rid of tamsulosin, which could cause the drug to build up in your blood. This might lead to more side effects from the medicine.
FDA Label Information
Tamsulosin hydrochloride capsules should be used with caution in combination with moderate inhibitors of CYP3A4 (e.g., erythromycin), in combination with strong (e.g., paroxetine) or moderate (e.g., terbinafine) inhibitors of CYP2D6, or in patients known to be CYP2D6 poor metabolizers, particularly at a dose higher than 0.4 mg (e.g., 0.8 mg). The effects of concomitant administration of a moderate CYP3A4 inhibitor (e.g., erythromycin) on the pharmacokinetics of tamsulosin hydrochloride have not been evaluated [see Warnings and Precautions (5.2) and Clinical Pharmacology (12.3)].
Tamsulosin Also Interacts With
- Furosemide major
- Paroxetine moderate
- Warfarin moderate
- Terbinafine moderate
- Dutasteride moderate
Erythromycin Also Interacts With
- Eplerenone major
- Pitavastatin major
- Risperidone major
- Sildenafil major
- Lefamulin moderate
Frequently Asked Questions
What SPL severity band is on file for Tamsulosin + Erythromycin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Erythromycin has 63 labeled pairs on file vs Tamsulosin's 18. In the moderate band specifically: Tamsulosin has 8 (also Paroxetine, Warfarin, Terbinafine, Dutasteride); Erythromycin has 6 (also Lefamulin, Lovastatin, Midazolam, Pravastatin).
What mechanism field is on file for Tamsulosin and Erythromycin?
Erythromycin may slow down the way your body gets rid of tamsulosin, which could cause the drug to build up in your blood. This might lead to more side effects from the medicine.
Erythromycin carries more major-labeled pairs than Tamsulosin
SPL source-record counts only. This page's band is moderate · classes on file: Tamsulosin (Alpha-1 Adrenergic Blocker); Erythromycin (Macrolide Antibiotic).
Erythromycin has 4 major-labeled pairs vs Tamsulosin's 1. This page itself is in the moderate band, not the major band.
1 major · 8 moderate · 9 minor · 18 total
- Other moderate peers for Tamsulosin
- Paroxetine
- Warfarin
- Terbinafine
- Dutasteride
4 major · 6 moderate · 53 minor · 63 total
- Other moderate peers for Erythromycin
- Lefamulin
- Lovastatin
- Midazolam
- Pravastatin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.