Tadalafil and Warfarin Interaction
Drug interaction information between Tadalafil and Warfarin.
Tadalafil and Warfarin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Tadalafil and Warfarin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Tadalafil does not change the amount of warfarin in the body or interfere with its ability to thin the blood.
FDA Label Information
Warfarin) — Tadalafil had no significant effect on exposure (AUC) to S-warfarin or R-warfarin, nor did tadalafil affect changes in prothrombin time induced by warfarin.
Tadalafil Also Interacts With
- Hydralazine/Isosorbide Dinitrate major
- Clarithromycin moderate
- Nirmatrelvir/Ritonavir moderate
- Amlodipine minor
- Metoprolol minor
Warfarin Also Interacts With
- Fluoxetine major
- Tamoxifen major
- Ibuprofen moderate
- Aspirin moderate
- Diclofenac moderate
Frequently Asked Questions
What SPL severity band is on file for Tadalafil + Warfarin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Warfarin has 163 labeled pairs on file vs Tadalafil's 25. In the minor band specifically: Tadalafil has 22 (also Amlodipine, Metoprolol, Tamsulosin, Aspirin); Warfarin has 133 (also Atorvastatin, Amlodipine, Omeprazole, Famotidine).
What mechanism field is on file for Tadalafil and Warfarin?
Tadalafil does not change the amount of warfarin in the body or interfere with its ability to thin the blood.
Warfarin carries more major-labeled pairs than Tadalafil
SPL source-record counts only. This page's band is minor · classes on file: Tadalafil (PDE5 Inhibitor); Warfarin (Vitamin K Antagonist (Anticoagulant)).
Warfarin has 2 major-labeled pairs vs Tadalafil's 1. This page itself is in the minor band, not the major band.
1 major · 2 moderate · 22 minor · 25 total
- Other minor peers for Tadalafil
- Amlodipine
- Metoprolol
- Tamsulosin
- Aspirin
2 major · 28 moderate · 133 minor · 163 total
- Other minor peers for Warfarin
- Atorvastatin
- Amlodipine
- Omeprazole
- Famotidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.