What the FDA labels say about taking them together
Metoprolol and tadalafil
Tadalafil's FDA label of June 3, 2026 names metoprolol in its drug interactions section; the metoprolol labels PlainMeds reads (4) do not name tadalafil.
Check it at the source: the metoprolol FDA label on DailyMed (effective March 3, 2026, Melinta Therapeutics, LLC); the tadalafil FDA label on DailyMed (effective June 3, 2026, Eli Lilly and Company).
What does the metoprolol label say about tadalafil?
Metoprolol's label (effective March 3, 2026) and its 3 other brand-application labels do not name tadalafil in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (TOPROL XL), Melinta Therapeutics, LLC, effective March 3, 2026 (SPL set 496ddfaa-7c9c-4888-b747-a210249b367a), via openFDA; the full label on DailyMed
What does the tadalafil label say about metoprolol?
Tadalafil label, drug interactionsClinical pharmacology studies were conducted to assess the effect of tadalafil on the potentiation of the blood-pressure-lowering effects of selected antihypertensive medications (amlodipine, angiotensin II receptor blockers, bendrofluazide, enalapril, and metoprolol).
Source: FDA drug label (Adcirca, NDA022332), United Therapeutics Corporation, effective December 15, 2025 (SPL set ff61b237-be8e-461b-8114-78c52a8ad0ae), via openFDA
Source: FDA drug label (Cialis), Eli Lilly and Company, effective June 3, 2026 (SPL set bcd8f8ab-81a2-4891-83db-24a0b0e25895), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Metoprolol | Tadalafil | |
|---|---|---|
| Labeled for | High blood pressure, Angina, Heart failure, Heart attack and coronary artery disease | Erectile dysfunction, Enlarged prostate (BPH), Pulmonary arterial hypertension |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.085 per tablet 100 mg tablet | $0.167 per tablet 20 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once