Tadalafil and Metoprolol Interaction
Drug interaction information between Tadalafil and Metoprolol.
Tadalafil and Metoprolol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Tadalafil and Metoprolol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These drugs both work to lower blood pressure, which can lead to a combined effect that lowers pressure more than intended.
FDA Label Information
Clinical pharmacology studies were conducted to assess the effect of tadalafil on the potentiation of the blood-pressure-lowering effects of selected antihypertensive medications (amlodipine, angiotensin II receptor blockers, bendrofluazide, enalapril, and metoprolol).
Tadalafil Also Interacts With
- Hydralazine/Isosorbide Dinitrate major
- Clarithromycin moderate
- Nirmatrelvir/Ritonavir moderate
- Amlodipine minor
- Tamsulosin minor
Metoprolol Also Interacts With
- Theophylline major
- Clonidine moderate
- Diltiazem moderate
- Verapamil moderate
- Fluoxetine minor
Frequently Asked Questions
What SPL severity band is on file for Tadalafil + Metoprolol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Tadalafil has 25 labeled pairs on file vs Metoprolol's 18. In the minor band specifically: Tadalafil has 22 (also Amlodipine, Tamsulosin, Aspirin, Warfarin); Metoprolol has 14 (also Fluoxetine, Paroxetine, Propafenone, Epinephrine).
What mechanism field is on file for Tadalafil and Metoprolol?
These drugs both work to lower blood pressure, which can lead to a combined effect that lowers pressure more than intended.
Tadalafil's labeled portfolio outnumbers Metoprolol
SPL source-record counts only. This page's band is minor · classes on file: Tadalafil (PDE5 Inhibitor); Metoprolol (Beta-Blocker).
1 major · 2 moderate · 22 minor · 25 total
- Other minor peers for Tadalafil
- Amlodipine
- Tamsulosin
- Aspirin
- Warfarin
1 major · 3 moderate · 14 minor · 18 total
- Other minor peers for Metoprolol
- Fluoxetine
- Paroxetine
- Propafenone
- Epinephrine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.