Tadalafil and Clarithromycin Interaction
Drug interaction information between Tadalafil and Clarithromycin.
Tadalafil and Clarithromycin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Tadalafil and Clarithromycin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Clarithromycin stops the body from breaking down tadalafil properly. This leads to higher levels of tadalafil in your blood, which can increase the risk of side effects.
FDA Label Information
Phosphodiesterase inhibitors: Sildenafil Tadalafil Vardenafil Use With Caution Sildenafil, Tadalafil, Vardenafil: Each of these phosphodiesterase inhibitors is primarily metabolized by CYP3A, and CYP3A will be inhibited by concomitant administration of clarithromycin. Co-administration of clarithromycin with sildenafil, tadalafil, or vardenafil will result in increased exposure of these phosphodiesterase inhibitors.
Tadalafil Also Interacts With
- Hydralazine/Isosorbide Dinitrate major
- Nirmatrelvir/Ritonavir moderate
- Amlodipine minor
- Metoprolol minor
- Tamsulosin minor
Clarithromycin Also Interacts With
- Quetiapine major
- Pioglitazone major
- Fluconazole major
- Cyclosporine major
- Lurasidone major
Frequently Asked Questions
What SPL severity band is on file for Tadalafil + Clarithromycin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clarithromycin has 81 labeled pairs on file vs Tadalafil's 25. In the moderate band specifically: Tadalafil has 2 (also Nirmatrelvir/Ritonavir); Clarithromycin has 35 (also Omeprazole, Methylprednisolone, Sildenafil, Valproate).
What mechanism field is on file for Tadalafil and Clarithromycin?
Clarithromycin stops the body from breaking down tadalafil properly. This leads to higher levels of tadalafil in your blood, which can increase the risk of side effects.
Clarithromycin carries more major-labeled pairs than Tadalafil
SPL source-record counts only. This page's band is moderate · classes on file: Tadalafil (PDE5 Inhibitor); Clarithromycin (Macrolide Antibiotic).
Clarithromycin has 16 major-labeled pairs vs Tadalafil's 1. This page itself is in the moderate band, not the major band.
1 major · 2 moderate · 22 minor · 25 total
- Other moderate peers for Tadalafil
- Nirmatrelvir/Ritonavir
16 major · 35 moderate · 30 minor · 81 total
- Other moderate peers for Clarithromycin
- Omeprazole
- Methylprednisolone
- Sildenafil
- Valproate
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.