What the FDA labels say about taking them together
Aspirin and tadalafil
Tadalafil's FDA label of June 3, 2026 names aspirin in its drug interactions section; the aspirin label PlainMeds reads does not name tadalafil. The tadalafil label: “When administered in combination with aspirin, tadalafil 20 mg did not prolong bleeding time, relative to aspirin alone.”
Check it at the source: the aspirin FDA label on DailyMed (effective September 9, 2025); the tadalafil FDA label on DailyMed (effective June 3, 2026, Eli Lilly and Company).
What does the aspirin label say about tadalafil?
Aspirin's label (effective September 9, 2025) does not name tadalafil in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Medique Products Aspirin), Unifirst First Aid Corporation, effective September 9, 2025 (SPL set 9b28fed0-a993-ca72-e053-2995a90ac7fd), via openFDA; the full label on DailyMed
What does the tadalafil label say about aspirin?
Tadalafil label, drug interactionsPotential for CIALIS to Affect Other Drugs Aspirin – Tadalafil did not potentiate the increase in bleeding time caused by aspirin.
Tadalafil label, warnings and precautionsWhen administered in combination with aspirin, tadalafil 20 mg did not prolong bleeding time, relative to aspirin alone.
Source: FDA drug label (Cialis), Eli Lilly and Company, effective June 3, 2026 (SPL set bcd8f8ab-81a2-4891-83db-24a0b0e25895), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aspirin | Tadalafil | |
|---|---|---|
| Labeled for | Pain, Cough and cold, Fever | Erectile dysfunction, Enlarged prostate (BPH), Pulmonary arterial hypertension |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0142 per tablet 81 mg tablet | $0.167 per tablet 20 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once