Tadalafil and Aspirin Interaction
Drug interaction information between Tadalafil and Aspirin.
Tadalafil and Aspirin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Tadalafil and Aspirin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Tadalafil does not increase the risk of bleeding or change how aspirin affects the blood's ability to clot.
FDA Label Information
7.3 Potential for Tadalafil Tablets to Affect Other Drugs Aspirin — Tadalafil did not potentiate the increase in bleeding time caused by aspirin.
Tadalafil Also Interacts With
- Hydralazine/Isosorbide Dinitrate major
- Clarithromycin moderate
- Nirmatrelvir/Ritonavir moderate
- Amlodipine minor
- Metoprolol minor
Aspirin Also Interacts With
- Atenolol major
- Fluoxetine major
- Ibandronate major
- Alendronate moderate
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Tadalafil + Aspirin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Aspirin has 47 labeled pairs on file vs Tadalafil's 25. In the minor band specifically: Tadalafil has 22 (also Amlodipine, Metoprolol, Tamsulosin, Warfarin); Aspirin has 32 (also Carisoprodol, Celecoxib, Colestipol, Diflunisal).
What mechanism field is on file for Tadalafil and Aspirin?
Tadalafil does not increase the risk of bleeding or change how aspirin affects the blood's ability to clot.
Aspirin carries more major-labeled pairs than Tadalafil
SPL source-record counts only. This page's band is minor · classes on file: Tadalafil (PDE5 Inhibitor); Aspirin (Antiplatelet / NSAID).
Aspirin has 3 major-labeled pairs vs Tadalafil's 1. This page itself is in the minor band, not the major band.
1 major · 2 moderate · 22 minor · 25 total
- Other minor peers for Tadalafil
- Amlodipine
- Metoprolol
- Tamsulosin
- Warfarin
3 major · 12 moderate · 32 minor · 47 total
- Other minor peers for Aspirin
- Carisoprodol
- Celecoxib
- Colestipol
- Diflunisal
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.