metoprolol vs tadalafil
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Side-by-side comparison of metoprolol and tadalafil. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Clinical pharmacology studies were conducted to assess the effect of tadalafil on the potentiation of the blood-pressure-lowering effects of selected antihypertensive medications (amlodipine, angiotensin II receptor blockers, bendrofluazide, enalapril, and metoprolol).
Lopressor, Toprol-XL
Cialis
Metoprolol is a beta-blocker medicine. It can lower blood pressure, reduce chest pain, and improve survival after a heart attack.
Tadalafil (Cialis) is a medicine that helps men with erectile dysfunction (ED) or enlarged prostate (BPH). It belongs to a class of drugs called PDE5 inhibitors.
Metoprolol treats high blood pressure (hypertension). Lowering blood pressure reduces the risk of strokes and heart attacks. It also treats chest pain called angina. After a heart attack, it can help you live longer.
This medicine can help men who have trouble getting or keeping an erection (ED). It can also treat the symptoms of an enlarged prostate, also known as benign prostatic hyperplasia (BPH). BPH can cause difficulty with urination.
Metoprolol blocks the effects of adrenaline on the heart. This makes the heart beat slower and with less force. As a result, blood pressure is lowered and the heart does not need as much oxygen.
Tadalafil works by relaxing the muscles in the penis and prostate. This increases blood flow to these areas. For BPH, it relaxes muscles in the prostate and bladder, which can improve urinary symptoms.
- • Tiredness
- • Dizziness
- • Depression
- • Shortness of breath
- • Slow heart rate
- • Headache
- • Upset stomach
- • Back pain
- • Muscle aches
- • Nasal congestion
- Fatigue 15,966
- Dyspnoea 14,128
- Diarrhoea 13,635
- Nausea 13,398
- Dizziness 11,699
- Dyspnoea 11,663
- Headache 10,690
- Diarrhoea 7,799
- Nausea 6,498
- Death 5,899
Stopping metoprolol suddenly can make chest pain worse or cause a heart attack. If you have heart failure, it could get worse. If you have asthma or other lung problems, avoid beta-blockers if possible.
If you have chest pain, tell your doctor. If you need nitrates for a heart problem, wait 48 hours after taking tadalafil before taking nitrates. If you get an erection that lasts more than 4 hours, get medical help right away. If you have sudden vision loss in one or both eyes, stop taking this medicine and get medical help right away. If you have a sudden decrease or loss of hearing, stop taking this medicine and get medical help right away.
Tell your doctor if you are pregnant or plan to become pregnant. Metoprolol can cross the placenta, and may cause low blood pressure, low blood sugar, and a slow heart rate in the newborn. Talk to your doctor about the risks and benefits.
This medicine is not for use in women. It is not known if this medicine will harm an unborn baby. It is also not known if this medicine passes into breast milk.
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How to Read This metoprolol vs tadalafil Comparison
metoprolol is classified in the Beta-Blocker drug class, while tadalafil sits within the PDE5 Inhibitor class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, metoprolol has 68,826 submissions while tadalafil has 42,549. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to these drugs both work to lower blood pressure, which can lead to a combined effect that lowers pressure more than intended.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for metoprolol or tadalafil.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.