Sofosbuvir/Velpatasvir and Rosuvastatin Interaction
Drug interaction information between Sofosbuvir/Velpatasvir and Rosuvastatin.
Sofosbuvir/Velpatasvir and Rosuvastatin have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Sofosbuvir/Velpatasvir and Rosuvastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This hepatitis C medication can increase the amount of rosuvastatin that stays in your blood.
FDA Label Information
Intervention: Sofosbuvir/velpatasvir/voxilaprevir Ledipasvir/sofosbuvir Avoid concomitant use with rosuvastatin. Simeprevir Dasabuvir/ombitasvir/paritaprevir/ritonavir Elbasvir/grazoprevir Sofosbuvir/velpatasvir Glecaprevir/pibrentasvir Atazanavir/ritonavir Lopinavir/ritonavir Initiate with rosuvastatin 5 mg once daily, and do not exceed a dose of rosuvastatin 10 mg once daily.
Sofosbuvir/Velpatasvir Also Interacts With
- Rifampin major
- Rosuvastatin/Ezetimibe major
- Pravastatin moderate
- Methotrexate moderate
- Cyclosporine moderate
Rosuvastatin Also Interacts With
- Glecaprevir/Pibrentasvir major
- Febuxostat major
- Cyclosporine moderate
- Ledipasvir/Sofosbuvir moderate
- Colchicine moderate
Frequently Asked Questions
What SPL severity band is on file for Sofosbuvir/Velpatasvir + Rosuvastatin?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Sofosbuvir/Velpatasvir has 33 labeled pairs on file vs Rosuvastatin's 21. In the major band specifically: Sofosbuvir/Velpatasvir has 3 (also Rifampin, Rosuvastatin/Ezetimibe); Rosuvastatin has 3 (also Glecaprevir/Pibrentasvir, Febuxostat).
What mechanism field is on file for Sofosbuvir/Velpatasvir and Rosuvastatin?
This hepatitis C medication can increase the amount of rosuvastatin that stays in your blood.
Sofosbuvir/Velpatasvir's labeled portfolio outnumbers Rosuvastatin
SPL source-record counts only. This page's band is major · classes on file: Sofosbuvir/Velpatasvir (NS5B/NS5A Inhibitor (HCV)); Rosuvastatin (HMG-CoA Reductase Inhibitor (Statin)).
3 major · 10 moderate · 20 minor · 33 total
- Other major peers for Sofosbuvir/Velpatasvir
- Rifampin
- Rosuvastatin/Ezetimibe
3 major · 8 moderate · 10 minor · 21 total
- Other major peers for Rosuvastatin
- Glecaprevir/Pibrentasvir
- Febuxostat
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.