Sofosbuvir/Velpatasvir and Pravastatin Interaction
Drug interaction information between Sofosbuvir/Velpatasvir and Pravastatin.
Sofosbuvir/Velpatasvir and Pravastatin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Sofosbuvir/Velpatasvir and Pravastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This medication increases the amount of pravastatin that stays in your blood, which makes muscle injury more likely.
FDA Label Information
HMG-CoA Reductase Inhibitors: pravastatin ↑ pravastatin Coadministration of VOSEVI with pravastatin has been shown to increase the concentration of pravastatin, which is associated with increased risk of myopathy, including rhabdomyolysis. Pravastatin may be administered with VOSEVI at a dose that does not exceed pravastatin 40 mg.
Sofosbuvir/Velpatasvir Also Interacts With
- Rifampin major
- Rosuvastatin major
- Rosuvastatin/Ezetimibe major
- Methotrexate moderate
- Cyclosporine moderate
Pravastatin Also Interacts With
- Cyclosporine moderate
- Erythromycin moderate
- Clarithromycin moderate
- Colchicine moderate
- Gemfibrozil moderate
Frequently Asked Questions
What SPL severity band is on file for Sofosbuvir/Velpatasvir + Pravastatin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Sofosbuvir/Velpatasvir has 33 labeled pairs on file vs Pravastatin's 16. In the moderate band specifically: Sofosbuvir/Velpatasvir has 10 (also Methotrexate, Cyclosporine, Carbamazepine, Amiodarone); Pravastatin has 9 (also Cyclosporine, Erythromycin, Clarithromycin, Colchicine).
What mechanism field is on file for Sofosbuvir/Velpatasvir and Pravastatin?
This medication increases the amount of pravastatin that stays in your blood, which makes muscle injury more likely.
Sofosbuvir/Velpatasvir carries more major-labeled pairs than Pravastatin
SPL source-record counts only. This page's band is moderate · classes on file: Sofosbuvir/Velpatasvir (NS5B/NS5A Inhibitor (HCV)); Pravastatin (HMG-CoA Reductase Inhibitor (Statin)).
Sofosbuvir/Velpatasvir has 3 major-labeled pairs vs Pravastatin's 0. This page itself is in the moderate band, not the major band.
3 major · 10 moderate · 20 minor · 33 total
- Other moderate peers for Sofosbuvir/Velpatasvir
- Methotrexate
- Cyclosporine
- Carbamazepine
- Amiodarone
0 major · 9 moderate · 7 minor · 16 total
- Other moderate peers for Pravastatin
- Cyclosporine
- Erythromycin
- Clarithromycin
- Colchicine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.