Sofosbuvir/Velpatasvir and Cyclosporine Interaction
Drug interaction information between Sofosbuvir/Velpatasvir and Cyclosporine.
Sofosbuvir/Velpatasvir and Cyclosporine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Sofosbuvir/Velpatasvir and Cyclosporine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Cyclosporine blocks the way your body clears one of the ingredients in this medicine, which can significantly increase the amount of drug in your blood.
FDA Label Information
The use of OATP inhibitors which may substantially increase exposure of voxilaprevir (e.g., cyclosporine) with VOSEVI is not recommended [see Clinical Pharmacology (12.3) ]. Immunosuppressants: cyclosporine ↑ voxilaprevir Coadministration of voxilaprevir with cyclosporine has been shown to substantially increase the plasma concentration of voxilaprevir, the safety of which has not been established. Coadministration of VOSEVI with cyclosporine is not recommended.
Sofosbuvir/Velpatasvir Also Interacts With
- Rifampin major
- Rosuvastatin major
- Rosuvastatin/Ezetimibe major
- Pravastatin moderate
- Methotrexate moderate
Cyclosporine Also Interacts With
- Clarithromycin major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Pitavastatin major
- Simvastatin major
Frequently Asked Questions
What SPL severity band is on file for Sofosbuvir/Velpatasvir + Cyclosporine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cyclosporine has 89 labeled pairs on file vs Sofosbuvir/Velpatasvir's 33. In the moderate band specifically: Sofosbuvir/Velpatasvir has 10 (also Pravastatin, Methotrexate, Carbamazepine, Amiodarone); Cyclosporine has 24 (also Aliskiren, Allopurinol, Amiloride, Amlodipine/Valsartan).
What mechanism field is on file for Sofosbuvir/Velpatasvir and Cyclosporine?
Cyclosporine blocks the way your body clears one of the ingredients in this medicine, which can significantly increase the amount of drug in your blood.
Cyclosporine carries more major-labeled pairs than Sofosbuvir/Velpatasvir
SPL source-record counts only. This page's band is moderate · classes on file: Sofosbuvir/Velpatasvir (NS5B/NS5A Inhibitor (HCV)); Cyclosporine (Calcineurin Inhibitor (Immunosuppressant)).
Cyclosporine has 5 major-labeled pairs vs Sofosbuvir/Velpatasvir's 3. This page itself is in the moderate band, not the major band.
3 major · 10 moderate · 20 minor · 33 total
- Other moderate peers for Sofosbuvir/Velpatasvir
- Pravastatin
- Methotrexate
- Carbamazepine
- Amiodarone
5 major · 24 moderate · 60 minor · 89 total
- Other moderate peers for Cyclosporine
- Aliskiren
- Allopurinol
- Amiloride
- Amlodipine/Valsartan
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.