Sofosbuvir/Velpatasvir and Rifampin Interaction
Drug interaction information between Sofosbuvir/Velpatasvir and Rifampin.
Sofosbuvir/Velpatasvir and Rifampin have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Sofosbuvir/Velpatasvir and Rifampin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Rifampin causes your body to process the hepatitis C medicine too quickly, which lowers the amount of medicine in your blood.
FDA Label Information
Antimycobacterials: rifampin ↓ sofosbuvir ↓ velpatasvir ↑ voxilaprevir (single dose) ↓ voxilaprevir (multiple dose) Coadministration with rifampin is contraindicated [see Contraindications (4) ].
Sofosbuvir/Velpatasvir Also Interacts With
- Rosuvastatin major
- Rosuvastatin/Ezetimibe major
- Pravastatin moderate
- Methotrexate moderate
- Cyclosporine moderate
Rifampin Also Interacts With
- Darunavir major
- Bictegravir/Emtricitabine/Tenofovir major
- Glecaprevir/Pibrentasvir major
- Nirmatrelvir/Ritonavir major
- Pitavastatin major
Frequently Asked Questions
What SPL severity band is on file for Sofosbuvir/Velpatasvir + Rifampin?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rifampin has 137 labeled pairs on file vs Sofosbuvir/Velpatasvir's 33. In the major band specifically: Sofosbuvir/Velpatasvir has 3 (also Rosuvastatin, Rosuvastatin/Ezetimibe); Rifampin has 8 (also Darunavir, Bictegravir, Glecaprevir/Pibrentasvir, Nirmatrelvir/Ritonavir).
What mechanism field is on file for Sofosbuvir/Velpatasvir and Rifampin?
Rifampin causes your body to process the hepatitis C medicine too quickly, which lowers the amount of medicine in your blood.
Rifampin carries more major-labeled pairs than Sofosbuvir/Velpatasvir
SPL source-record counts only. This page's band is major · classes on file: Sofosbuvir/Velpatasvir (NS5B/NS5A Inhibitor (HCV)); Rifampin (Rifamycin Antibiotic).
Rifampin has 8 major-labeled pairs vs Sofosbuvir/Velpatasvir's 3.
3 major · 10 moderate · 20 minor · 33 total
- Other major peers for Sofosbuvir/Velpatasvir
- Rosuvastatin
- Rosuvastatin/Ezetimibe
8 major · 26 moderate · 103 minor · 137 total
- Other major peers for Rifampin
- Darunavir
- Bictegravir
- Glecaprevir/Pibrentasvir
- Nirmatrelvir/Ritonavir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.