Sofosbuvir/Velpatasvir and Rosuvastatin/Ezetimibe Interaction
Drug interaction information between Sofosbuvir/Velpatasvir and Rosuvastatin/Ezetimibe.
Sofosbuvir/Velpatasvir and Rosuvastatin/Ezetimibe have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Sofosbuvir/Velpatasvir and Rosuvastatin/Ezetimibe. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This antiviral medicine increases the amount of rosuvastatin in your system by changing how your body processes it. Higher levels of the drug can increase the risk of muscle damage.
FDA Label Information
Intervention: Sofosbuvir/velpatasvir/voxilaprevir Ledipasvir/sofosbuvir Avoid concomitant use with rosuvastatin. Simeprevir Dasabuvir/ombitasvir/paritaprevir/ritonavir Elbasvir/grazoprevir Sofosbuvir/velpatasvir Glecaprevir/pibrentasvir Atazanavir/ritonavir Lopinavir/ritonavir Initiate with rosuvastatin 5 mg once daily, and do not exceed a dose of rosuvastatin 10 mg once daily.
Sofosbuvir/Velpatasvir Also Interacts With
- Rifampin major
- Rosuvastatin major
- Pravastatin moderate
- Methotrexate moderate
- Cyclosporine moderate
Rosuvastatin/Ezetimibe Also Interacts With
- Glecaprevir/Pibrentasvir major
- Febuxostat major
- Rosuvastatin moderate
- Cyclosporine moderate
- Ledipasvir/Sofosbuvir moderate
Frequently Asked Questions
What SPL severity band is on file for Sofosbuvir/Velpatasvir + Rosuvastatin/Ezetimibe?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Sofosbuvir/Velpatasvir has 33 labeled pairs on file vs Rosuvastatin/Ezetimibe's 12. In the major band specifically: Sofosbuvir/Velpatasvir has 3 (also Rifampin, Rosuvastatin); Rosuvastatin/Ezetimibe has 3 (also Glecaprevir/Pibrentasvir, Febuxostat).
What mechanism field is on file for Sofosbuvir/Velpatasvir and Rosuvastatin/Ezetimibe?
This antiviral medicine increases the amount of rosuvastatin in your system by changing how your body processes it. Higher levels of the drug can increase the risk of muscle damage.
Sofosbuvir/Velpatasvir's labeled portfolio outnumbers Rosuvastatin/Ezetimibe
SPL source-record counts only. This page's band is major · classes on file: Sofosbuvir/Velpatasvir (NS5B/NS5A Inhibitor (HCV)); Rosuvastatin/Ezetimibe (Statin / Cholesterol Absorption Inhibitor).
3 major · 10 moderate · 20 minor · 33 total
- Other major peers for Sofosbuvir/Velpatasvir
- Rifampin
- Rosuvastatin
3 major · 7 moderate · 2 minor · 12 total
- Other major peers for Rosuvastatin/Ezetimibe
- Glecaprevir/Pibrentasvir
- Febuxostat
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.